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Darbepoetin Alfa Injection
darbepoetin alfa is used to treat anemia (low red blood cell count) in people with long-term serious kidney disease (chronic kidney failure) and people receiving chemotherapy for some types of cancer (cancer that does not involve the bone marrow or blood cells).

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darbepoetin alfa

  • API: darbepoetin alfa
  • Packaging: injection, for intravenous or subcutaneous use
  • Strength: Single-dose vials: 25, 40, 60, 100, 200, 300, and 500 mcg/1 mL, and 150 mcg/0.75 mL
    Single-dose prefilled syringes: 25 mcg/0.42mL, 40 mcg/,0.4mL, 60 mcg/0.3 mL, 100 mcg/0.5 mL, 150 mcg/0.3 mL, 200 mcg/0.4 mL, 300 mcg/0.6 mL, and 500 mcg/1 mL


darbepoetin alfa is an erythropoiesis-stimulating protein that is produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology. Aranesp is a 165-amino acid protein that differs from recombinant human erythropoietin in containing 5 N-linked oligosaccharide chains, whereas recombinant human erythropoietin contains 3 chains. The 2 additional N-glycosylation sites result from amino acid substitutions in the erythropoietin peptide backbone.

darbepoetin alfa is an erythropoiesis-stimulating agent (ESA) indicated for the treatment of anemia due to: • Chronic Kidney Disease (CKD) in patients on dialysis and patients not on dialysis. • The effects of concomitant myelosuppressive chemotherapy, and upon initiation, there is a minimum of two additional months of planned chemotherapy.

Note: (For Prescribing Information Approved Drugs, see)

  • The Food and Drug Administration (FDA), USA.
  • The European Medicines Agency (EMA).

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