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Category: Hodgkin’s Disease
Lomustine
Description
This page contains brief details about the drug lomustine, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
The U.S. FDA approved lomustine in 1976. This medicine belongs to a group of monoclonal antibody (a protein made from specific immune cells).
Mechanism of Action of Lomustine
Lomustine works by damaging the DNA and RNA of the cancer cells. This stops their growth and multiplication.
Uses of Lomustine
It is mainly used to treat brain tumors (lumps formed from abnormal cells), lung tumors, Hodgkin’s disease (cancer of lymph system, a part of the immune system), and malignant melanoma (skin cancer).
Lomustine Dosage available
The medicine will be administered to you by a healthcare professional in a hospital setting. It is usually administered in the vein (intravenous). Your doctor will decide the dose, route of administration, and frequency based on your disease condition and other factors.
Chlorambucil
Description
This page contains brief details about the drug chlorambucil, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Chlorambucil is an anticancer drug that belongs to the class of medications called alkylating agents. FDA approved it initially on November 1, 2013, for treating some types of cancer and certain blood problems.
Mechanism of Action of Chlorambucil
Chlorambucil is an aromatic nitrogen mustard derivative and alkylating agent that interferes with DNA replication. It also induces cellular apoptosis by the accumulation of protein cytosolic p53 and activation of BAX, an cell death promoter. It works by reducing the number of abnormal cells your body makes.
Uses of Chlorambucil
Chlorambucil is available as a tablet. It is used to treat Hodgkin’s disease and non-hodgkin’s lymphoma (cancers formed from cells of the lymphatic system). It is also indicated to treat chronic lymphocytic leukemia (A type of WBC cancer, where the bone marrow produces a large number of abnormal cells) and Waldenstrom’s macroglobulinemia (A rare lymphoma associated with an uncontrolled increase of B-cells, a type of white blood cell, resulting in the release of an abnormal protein into the blood.)
Chlorambucil Dosage available
Chlorambucil is available as an oral prescription drug. It is available in two doses 200mg and 400mg. Your doctor will decide the dose, and duration of the therapy based on your disease status, severity, and other factors such as body weight, other disease conditions, and age. Always take this medicine as prescribed by your doctor. Take the tablet daily on an empty stomach at least one hour before meals or three hours after meals. Do not break, chew, crush, or break the tablet. Swallow the whole tablet with water.
Etoposide
Description
This page contains brief details about the drug etoposide, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
ETOPOSIDEThe U.S. FDA approved Etoposide as an anticancer medication to treat a certain type of cancer on 11th April 1983.
Mechanism of Action of Etoposide
Etoposide works by inhibiting the activity of topoisomerase II (essential for cell replication) and DNA synthesis, which will prevent cancer cells from growing and multiplying, ultimately leading to cell death.
Uses of Etoposide
Etoposide treats testicular, small-cell lung, acute myeloid leukemiaacute myeloid leukemia (blood cancer), Hodgkin’s and non-Hodgkin’s lymphoma, and ovarian cancer. This medicine can prevent the proliferation of cancer cells and prevents cell division which ultimately leads to cell death.
Etoposide Dosage available
It is an intravenous infusion drug that is injected through the veins. Your physician will choose the dosage and administration frequency based on your medical condition because it differs for each person.