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Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticosteroids in the adrenal cortex. Tetracosactide exhibits the same activity as natural ACTH with regard to all its biological activities. The complex results in a product whose absorption in man is effected over a longer period of time as compared to corticotropin. Therefore, therapy may be maintained with less frequent administration.
Tetracosactide Acetate Injection
- Generic Brand Available – Synacthen Ampoules
- API – Tetracosactide Acetate
- Packaging – Glass Bottle
- Strength – 250 mcg
What is Tetracosactide Acetate used for?
Tetracosactide acetate consists of the first 24 amino acids occurring in the ACTH sequence and displays the same physiological properties as ACTH. In the adrenal cortex, it stimulates the biosynthesis of glucocorticoids, mineralocorticoids, and, to a lesser extent androgens.
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Facts of Medicines
STORAGE AND HANDLING
Tetracosactide Acetate Injection must be refrigerated at 2°C to 8°C (36°F to 46°F). Do not use the Tetracosactide Acetate Injection beyond the expiration date located on the carton and the vial.
Adults: This preparation of Synacthen is intended for administration for diagnostic purposes only as a single intramuscular or intravenous dose; it is not to be used for repeated therapeutic administration.
The 30-minute Synacthen diagnostic test: This test is based on measurement of the plasma cortisol concentration immediately before and exactly 30 minutes after an intramuscular or intravenous injection of 250 micrograms (1ml) Synacthen. Adrenocortical function can be regarded as normal if the post-injection rise in plasma cortisol concentration increases by 200 nmol/litre (70 micrograms/litre), i.e. if the value 30 minutes after injection is >500 nmol/litre (180 micrograms/litre), adrenocortical function is regarded as normal.
All the plasma samples should be stored in a refrigerator until plasma cortisol level estimation.
Where the 30-minute test has yielded inconclusive results, or where it is desired to determine the functional reserve of the adrenal cortex, a 5-hour test can be performed with Synacthen Depot (see separate Summary of Product Characteristics). Furthermore, a 3-day test with Synacthen Depot may be used to differentiate between primary and secondary adrenocortical insufficiency.
WARNINGS AND PRECAUTIONS
- Genetic testing should be indicated in order to detect whether a person is at higher risk of developing hypersensitivity.
- Tetracosactide Acetate Injection may not be added as a single agent when antiretroviral regimens are changed because of loss of the virologic response.
- Patients with liver disease should be watchful and cautious in order to Tetracosactide Acetate Injection because it can aggravate the condition.
- In patients with Tetracosactide Acetate Injection, conditions like immune reconstitution inflammatory syndrome, a change in body fat as well as an increased risk of heart attack may occur.
- Tetracosactide Acetate Injection is not recommended for use in infants who are under 3 months of age.
- Sometimes serious hypersensitivity reactions have been associated with Tetracosactide Acetate Injection.
Dizziness, drowsiness, nausea/vomiting, diarrhea, loss of appetite, or weakness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
FAQs – Medicine Questions
What is Tetracosactide used for?
What is Synacthen injection used for?
What is another name for Synacthen?
Where can I buy Tetracosactide Acetate Injection?
You can buy Tetracosactide Acetate Injection from any authorized whole-seller after getting a prescription from a qualified doctor. It is always better to check the credential of the whole-seller/supplier/exporter before buying the product.
The buyer should check the existing law in their home country before importing the product.
What is the procedure to buy Tetracosactide Acetate Injection?
Patients can simply fill the order form or can send mail at email@example.com. Patients can also send WhatsApp messages to +91 99292 77766 / 98738 10020 We will reply ASAP with the details of the Tetracosactide Acetate Injection price as well as procurement procedure.
Note:- The order will be confirmed only after the receipt of the Valid prescription of the Clinician.
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