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Denosumab Injection was approved on 2 June 2010, by the FDA for use in postmenopausal women with risk of osteoporosis.
Denosumab Injection
- Brand Name – On Request
- Innovator Brand Name – On Request
- API – Denosumab
- Packaging – Single-use prefilled syringe
- Strength – 60 mg
- Manufacturer Name – Amgen
What is Denosumab Injection used for?
Denosumab Injection is a RANKL inhibitor indicated:
- for treating increased bone mass in males at the higher risk for the fracture receiving androgen deprivation therapy for the nonmetastatic prostate cancer. In such patients this drug also reduced the incidence of the vertebral fractures.
- for treating increased bone mass in females at the high risk for the fracture receiving adjuvant aromatase inhibitor therapy for the breast cancer.
- for treating the postmenopausal females with the osteoporosis at the higher risk for a fracture, defined as the history of the osteoporotic fracture, or multiple risk factors for the fracture; or patients who have failed or are intolerant to the other existing osteoporosis therapy. In postmenopausal female with the osteoporosis, Prolia helps in reducing the incidence of the vertebral, nonvertebral, and also hip fractures.
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Get Access To Denosumab Injection price
Shreyaansh Lifesciences, Jaipur. India
Shreyaansh Lifesciences is registered in Jaipur, India. Registration Number : 08AEEFS9350K1ZI under GST Act.
Branch Offices in India : Jaipur | New Delhi
SF-72-73 2ND FLOOR, Jaipur Electronic Market, Ridhi Sidhi Choraha, Jaipur, Rajasthan, 302018.
+91 99292 77766
Facts of Medicines
DENOSUMAB DOSAGE
Denosumab injection should be administered by a healthcare professional. It should be Administered 60 mg every 6 months as a subcutaneous injection in the upper arm, upper thigh, or abdomen.
DENOSUMAB SIDE EFFECTS
- Postmenopausal osteoporosis: Most common adverse reactions include back pain, pain in extremity, hypercholesterolemia, cystitis, and musculoskeletal pain. Pancreatitis has been experienced in clinical trials.
- Bone loss due to hormone ablation for cancer: Most common denosumab side effects include arthralgia and back pain. Pain in extremity and musculoskeletal pain have also been experienced.
SUPPLIED/STORAGE AND HANDLING
Care should be exercised in the handling of this injection. prolia injection should not be opened or crushed. Store is permitted between 2°C to 8°C (36°F to 46°F). Should be stored in the original carton. Do not freeze it.
- Patients must be instructed in order to take calcium 1000 mg daily and at least 400 IU vitamin D daily
- If a prolia injection dosage is missed, administer the injection as soon as the patient is available. Thereafter, the injection should be scheduled every 6 months from the date of the last injection.
- Patients should be advised that the denosumab is also marketed as Xgeva, and if patients are receiving Prolia, they should avoid receiving Xgeva.
- Patients should be instructed in order to seek immediate medical assistance if they experience signs or symptoms of infections, including cellulitis.
- Patients should be advised in order to seek immediate medical attention if they experience signs or symptoms of dermatological reactions such as rashes, eczema and dermatitis.
- Prolia is not recommended in pediatric patients. The safety as well as the effectiveness profile of Denosumab in pediatric patients is unspecified.
- Take a lot of care of your teeth as well as gums while taking this medication.
- Patients must inform their healthcare provider or dentist if they observe persistent pain or slow healing of the mouth or jaw after the dental surgery.
- No dose adjustment is required in patients with renal impairment.
- Patients must be advised to seek immediate medical help if signs or symptoms of hypersensitivity reactions occur.
- Patients should be instructed if they have had signs or symptoms of the systemic hypersensitivity reactions they must not receive denosumab.
- Pregnancy status needs to be verified of females of reproductive potential before initiating treatment with Prolia 60 mg.
FAQs – Medicine Questions
How does Denosumab work in the human body?
Denosumab is a human IgG2 monoclonal antibody with affinity and specificity for human RANKL. It prevents RANKL from activating its receptor, preventing the RANKL/RANK interaction that inhibits osteoclast formation, function, and survival.
What is the use of Denosumab 60 mg injection?
It is basically is a biologic drug recommended to use in order to prevent the fragile bones, also called osteoporosis and bone fractures.
What contains Denosumab?
Denosumab is the active ingredient in the single-use prefilled syringe composed with other inactive ingredients sorbitol, acetate, polysorbate 20, Water, and sodium hydroxide.
Where can I buy Denosumab Injection?
You can buy Denosumab Injection from any authorized whole-seller after getting a prescription from a qualified doctor. It is always better to check the credential of the whole-seller/supplier/exporter before buying the product.
The buyer should check the existing law in their home country before importing the product.
What is the procedure to buyDenosumab Injection?
Patients can simply fill the order form or can send mail at info@treatmentoptions4u.com. Patients can also send WhatsApp messages to +91 98738 10020. We will reply ASAP with the details of the Denosumab Injection price as well as procurement procedure.
Note:- The order will be confirmed only after the receipt of the Valid prescription of the Clinician.
NEWS / UPDATES
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Agents affecting mineral ion homeostasis and bone turnover, 12th edition, 2011, 1299.
- KD Tripathi, Essentials of Medical Pharmacology, Drugs affecting calcium balance, 7th edition, 2013, 346.
- Amgen Inc, US Food and Drug Administration, [ Revised on March 2020] [ Accessed on 6th July 2021], https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/125320s205lbl.pdf
- Amgen Limited, Electronic medicines compendium (emc), [ Revised on June 2021] [ Accessed on 6th July 2021], https://www.medicines.org.uk/emc/files/pil.568.pdf
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