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Tazemetostat Tablets
Tazemetostat is a medication used for the treatment of adults and adolescents aged 16 years and older with metastatic (when cancer cells spread to other parts of the body) or locally advanced (when cancer has grown outside the organ it started in, but has not yet spread to distant parts of the body) epithelioid sarcoma not eligible for complete resection (surgically removing all of a tissue, structure, or organ).

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tazemetostat tablets

  • API: tazemetostat
  • Packaging: Tablets
  • Strength: Tablets: 200 mg


Tazemetostat is a cancer drug that acts as a potent selective EZH2 inhibitor. Tazemetostat blocks activity of the EZH2 methyltransferase, which may help keep the cancer cells from growing. Most cases of epithelioid sarcoma begin in the soft tissue under the skin of an extremity, though it can start in other areas of the body. Surgical removal is considered the main treatment when the cancer is localized to one area of the body. Chemotherapy or radiation may also be given. However, there is a high likelihood for local and regional spread of the disease even with treatment and approximately 50% of patients have metastatic disease at the time of diagnosis. Metastatic disease is considered life-threatening to the patient.

Note: (For Prescribing Information Approved Drugs, see)

  • The Food and Drug Administration (FDA), USA.
  • The European Medicines Agency (EMA).

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