Celkeran (Chlorambucil) Tablet

Description

Description

This page contains brief details about the drug chlorambucil, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Date of Approval

Chlorambucil is an anticancer drug that belongs to the class of medications called alkylating agents. FDA approved it initially on November 1, 2013, for treating some types of cancer and certain blood problems.

Mechanism of Action of Chlorambucil

Chlorambucil is an aromatic nitrogen mustard derivative and alkylating agent that interferes with DNA replication. It also induces cellular apoptosis by the accumulation of protein cytosolic p53 and activation of BAX, an cell death promoter. It works by reducing the number of abnormal cells your body makes.

Uses of Chlorambucil

Chlorambucil is available as a tablet. It is used to treat Hodgkin’s disease and non-hodgkin’s lymphoma (cancers formed from cells of the lymphatic system). It is also indicated to treat chronic lymphocytic leukemia (A type of WBC cancer, where the bone marrow produces a large number of abnormal cells) and Waldenstrom’s macroglobulinemia (A rare lymphoma associated with an uncontrolled increase of B-cells, a type of white blood cell, resulting in the release of an abnormal protein into the blood.)

Chlorambucil Dosage available

Chlorambucil is available as an oral prescription drug. It is available in two doses 200mg and 400mg. Your doctor will decide the dose, and duration of the therapy based on your disease status, severity, and other factors such as body weight, other disease conditions, and age. Always take this medicine as prescribed by your doctor. Take the tablet daily on an empty stomach at least one hour before meals or three hours after meals. Do not break, chew, crush, or break the tablet. Swallow the whole tablet with water.