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Abretone (Abiraterone Acetate) Tablets
Generic brands for Abiraterone Acetate Available in India Brand Name Abretone Generic Name Abiraterone Acetate Strength 250mg Manufacturer Cadila Pharmaceuticals Ltd.
Description
Description
This page contains brief details about the drug abiraterone acetate, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
On April 28, 2011, the U.S. FDA approved Abiraterone acetate to be used in Combination with prednisone for the treatment of patients with metastatic castration-resistant prostate cancer who have received prior chemotherapy containing docetaxel.
Mechanism of Action of Abiraterone Acetate
Prostate cancer occurs due to excessive production of male hormones (androgens/ testosterone). Androgens are produced by the testicles, adrenal glands and metastatic tumor. Abiraterone acetate works by interfering and inhibiting the enzyme CYP17A1 that acts as a catalyst in the production of the androgens. Inhibition of this enzyme, reduces the amount of androgens produced in the body.
Uses of Abiraterone Acetate
Abiraterone acetate is used in treatment of prostate cancer.
Abiraterone Acetate Dosage available
This medication is to be taken as prescribed by your doctor. Abiraterone acetate is administered orally (by mouth) and the recommended dose is 1000mg (two tablets) once a day. This medication is not to be taken with food and must be consumed whole without breaking it.
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References
1. Centocor Ortho Biotech Inc, US Food and drug administration, [ Revised date: APR 2011] [ Accessed date: 26 MAY 2022], https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/202379lbl.pdf
2. Janssen- Cilag International NV, Electronics Medicine Compendium (emc), [Revised date: SEP 2021] [ Accessed date: 26 MAY 2022] https://www.medicines.org.uk/emc/files/pil.2381.pdf
3. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Natural products in cancer chemotherapy: hormones and related agents, 12th edition, 2011, 1707 – 1709.