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Category: Acute Myeloid Leukemia (AML)
Midostaurin
Description
This page contains brief details about the drug midostaurin, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Midostaurin is an anticancer medication which was approved for its medical use on April 2017.
Mechanism of Action of Midostaurin
Midostaurin is an anticancer medication belonging to the category of medications called kinase inhibitors. It acts against the receptors and proteins that facilitate the mutation of FLT3 gene, interrupts cancer cell signaling, and eventually stops the growth and spread of cancer cells.
Uses of Midostaurin
Midostaurin is a prescription medicine developed to treat acute myeloid leukemia caused by a mutation in FLT3 genes. It is also indicated to treat aggressive system mast cytosis, systemic mast cytosis with hematological neoplasm, and mast cell leukemia.
Midostaurin Dosage available
Midostaurin is available in form of Capsules in the dose 25mg. The usual recommended dosing is 50mg twice daily with food for acute myeloid leukemia and 100mg twice daily for aggressive systemic mast cytosis and systemic mast cytosis. Swallow Midostaurin Capsule whole with a glass of water.
Daunorubicin
Description
This page contains brief details about the drug daunorubicin, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Daunorubicin is an anti-cancer drug containing the active constituent daunorubicin. This chemotherapy medication belongs to the anthracycline class of drugs. It is used in the treatment of leukemia. In leukemia, the white blood cells produced in the bone marrow multiply uncontrolled and abnormally. Leukemia is associated with severe infection, extreme tiredness, and joint pain. It is necessary to inform your doctor if you have an infection, cardiac diseases, mouth ulcers, chickenpox or shingles (viral infection), fever, radiation treatment to the chest, kidney stones, and liver disorders.
Daunorubicin was first approved by the FDA in 1979 for the treatment of acute myeloid leukemia (AML). Since then, Daunorubicin has been approved for additional indications and formulations, including for the treatment of solid tumors and lymphomas. Like many chemotherapy drugs, it can cause side effects such as nausea, vomiting, hair loss, fatigue, and an increased risk of infection due to its effect on the immune system.
Mechanism of Action of Daunorubicin
The therapeutic effect of daunorubicin is to inhibit the growth and replication of cancer cells. As a chemotherapy medication, daunorubicin works by binding to DNA and interfering with its replication and transcription, ultimately leading to cell death. Doing so can help shrink tumors, prevent cancer from spreading to other parts of the body, and potentially cure cancer in some cases.
Uses of Daunorubicin
Daunorubicin is primarily used to treat acute myeloid leukemia (AML), a type of cancer that affects the blood and bone marrow. It can also be used to treat other types of cancer, including acute lymphocytic leukemia (ALL), chronic myeloid leukemia (CML), lymphoma, and solid tumors such as breast and ovarian cancer.
Daunorubicin Dosage available
Daunorubicin is typically administered as an intravenous (IV) infusion or injection in a hospital or clinical setting by a healthcare provider. The exact dosing and frequency of administration will depend on the specific condition being treated and other individual factors, such as the patient’s age, weight, and overall health. If a dose is missed, it’s important to contact your healthcare provider as soon as possible to determine the appropriate course of action. Suppose the missed dose is discovered within a few hours of the scheduled time. In that case, your healthcare provider may recommend administering the missed dose as soon as possible while maintaining the usual interval between doses. However, if more than a few hours have passed since the missed dose, your healthcare provider may recommend skipping the missed dose and resuming the regular dosing schedule at the next scheduled time. It’s important not to double up on doses to make up for a missed one.
Etoposide
Description
This page contains brief details about the drug etoposide, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
ETOPOSIDEThe U.S. FDA approved Etoposide as an anticancer medication to treat a certain type of cancer on 11th April 1983.
Mechanism of Action of Etoposide
Etoposide works by inhibiting the activity of topoisomerase II (essential for cell replication) and DNA synthesis, which will prevent cancer cells from growing and multiplying, ultimately leading to cell death.
Uses of Etoposide
Etoposide treats testicular, small-cell lung, acute myeloid leukemiaacute myeloid leukemia (blood cancer), Hodgkin’s and non-Hodgkin’s lymphoma, and ovarian cancer. This medicine can prevent the proliferation of cancer cells and prevents cell division which ultimately leads to cell death.
Etoposide Dosage available
It is an intravenous infusion drug that is injected through the veins. Your physician will choose the dosage and administration frequency based on your medical condition because it differs for each person.