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Category: Bladder Inflammation
Mesna
Description
This page contains brief details about the drug mesna, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Mesna is a cytoprotectant drug that belongs to the class of hemorrhagic cystitis inhibitors. FDA-approved mesna initially on 1998 for the treatment of hemorrhagic cystitis.
Mechanism of Action of Mesna
Mesna reduces ifosfamide (cancer medication) induced hemorrhagic cystitis by binding to certain metabolites, inhibiting their toxic effects on the bladder.
Uses of Mesna
Mesna is an intravenously administered drug. This medicine is used to reduce the risk of hemorrhagic cystitis (a condition that causes bladder inflammation and can result in serious bleeding) in people who receive ifosfamide (a medication used for treating cancer). It protects against some of the harmful effects of certain chemotherapy medications.
Mesna Dosage available
Mesna is available as an intravenous injection. The drug should be administered only by healthcare professionals experienced with cancer chemotherapy. Your physician will determine the dose and frequency of administration based on the type of cancer and severity of the disease. Do not self-administer the injection.
Ifosfamide With Mesna
Description
This page contains brief details about the drug ifosfamide,mesna, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Ifosfamide, Mesna are alkylating agents and hemorrhagic cystitis inhibitors which was approved for its medical use in the year 1998.
Mechanism of Action of Ifosfamide With Mesna
These two combinations together work by damaging the DNA in cancer cells, which leads to cell death and slows the growth and spread of cancer. Mostly, this involves the formation of reactive metabolites in the liver, which are then transported to cancer cells in the body. These metabolites react with the DNA in the cancer cells, causing cross-links and breaks in the DNA strands. This interferes with the replication and transcription of DNA, leading to cell death.
Uses of Ifosfamide With Mesna
Ifosfamide, Mesna are indicated for the treatment of bladder inflammation, hemorrhagic cystitis and cancers in the soft tissues, germ cell, pancreas and cervix.
Ifosfamide With Mesna Dosage available
It will be given to you by a doctor or nurse in a hospital or clinic setting trained in cancer chemotherapy. Ifosfamide, Mesna is given as an intravenous infusion drip (into your vein). Do not self-administer the injection. Your doctor will decide the dose and duration of the treatment based on your disease severity, body weight, and other factors. Your doctor will give you certain medications to lessen the chance of getting side effects from the Ifosfamide, Mesna treatment.