treatmentoptions4u.com

Category: Cancer

  • Goserelin Acetate

    Description

    This page contains brief details about the drug goserelin acetate, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

    Date of Approval

    Goserelin Acetate is a gonadotropin-releasing hormone agonist. Goserelin Acetate 3.6mg implant was approved in 1989 whereas Goserelin Acetate 10.8mg was approved in 1996.

    Mechanism of Action of Goserelin Acetate

    Goserelin Acetate is a synthetic analogue of gonadotropin releasing hormone that binds to the gonadotropin receptors of pituitary gland. It lowers the androgen and testosterone levels in men and oestrogen levels in women. It is prescribed in combination with androgen antagonist like flutamide to prevent the initial flare up of tumor.

    Uses of Goserelin Acetate

    Goserelin Acetate Injection is an anticancer medication indicated for the palliative treatment of Advanced prostate cancer and breast cancer. It is also indicated as an endometrial thinning agent in uterine bleeding and for the management of endometriosis.

    Goserelin Acetate Dosage available

    Goserelin Acetate is available as a prefilled syringe indicated as an implant in the doses 3.6mg, and 10.8mg.  It is administered through subcutaneous route.

  • Mesna

    Description

    This page contains brief details about the drug mesna, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

    Date of Approval

    Mesna is a cytoprotectant drug that belongs to the class of hemorrhagic cystitis inhibitors.  FDA-approved mesna initially on 1998 for the treatment of hemorrhagic cystitis.

    Mechanism of Action of Mesna

    Mesna reduces ifosfamide (cancer medication) induced hemorrhagic cystitis by binding to certain metabolites, inhibiting their toxic effects on the bladder.

    Uses of Mesna

    Mesna is an intravenously administered drug. This medicine is used to reduce the risk of hemorrhagic cystitis (a condition that causes bladder inflammation and can result in serious bleeding) in people who receive ifosfamide (a medication used for treating cancer). It protects against some of the harmful effects of certain chemotherapy medications.

    Mesna Dosage available

    Mesna is available as an intravenous injection. The drug should be administered only by healthcare professionals experienced with cancer chemotherapy. Your physician will determine the dose and frequency of administration based on the type of cancer and severity of the disease. Do not self-administer the injection.

  • Atezolizumab

    Description

    This page contains brief details about the drug atezolizumab, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

    Date of Approval

    Atezolizumab is an anticancer drug belonging to the group of medicines called Programmed death ligand – 1 inhibitor (PDL-1). It was officially approved for its medical use in the year 2016.

    Mechanism of Action of Atezolizumab

    Atezolizumab is a humanized monoclonal antibody that belongs to the category of programmed death ligand – 1. Programmed death ligand is a protein that facilitates the suppression of T-cells by binding with immune and tumor cells. This leads to a poor immune response against cancer cells. Atezolizumab Injection acts against the signals of programmed death ligand – 1 and improves immune response by exhibiting specific cytotoxic activity.

    Uses of Atezolizumab

    Atezolizumab is indicated for various types of cancer as a monotherapy and also along with other anticancer medications. It is usually prescribed to treat urothelial carcinoma, liver cancer (hepatocellular carcinoma), small cell and non-small cell lung cancer, triple-negative breast cancer, and melanoma.

    Atezolizumab Dosage available

    Atezolizumab Injection is intended for intravenous administration. Your physician will inject this medicine as an infusion for the first 60 minutes and if it is well tolerated, the subsequent infusions will be administered for 30 minutes.

    Atezolizumab Injection is available as a single-use vial in doses 840mg/14ml and 1200mg/20ml. The ideal dosing for urothelial carcinoma, non-small cell and small cell lung cancers, hepatocellular carcinoma, and melanoma is 840mg every two weeks, 1200mg every 3 weeks, or 1680mg every four weeks.

  • Teicoplanin

    Description

    This page contains brief details about the drug teicoplanin, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

    Date of Approval

    Teicoplanin is an antibiotic that belongs to the class of medications called semisynthetic glycopeptide. The FDA approved this medicine for its use on 24 May 2018. FDA did not approve it for use in the USA.

    Mechanism of Action of Teicoplanin

    The cell wall of gram-positive bacteria is entirely made of peptidoglycan, which is necessary for cell wall synthesis. Teicoplanin interferes with the cell-wall biosynthesis of bacteria by binding to specific residues and inhibiting the polymer membrane. It works by killing the bacteria which can cause serious infections.

    Uses of Teicoplanin

    It is used in adults and children to treat bacterial infections of soft tissues, lungs, urinary tract, endocarditis, abdominal wall, blood, bones, and joints. It works by killing the bacteria that cause infections in the body.

    Teicoplanin Dosage available

    Teicoplanin is available as an injection. It will be given to you by a doctor or other healthcare professional. It will be given as an intravenous injection (into a vein) or intramuscular (into a muscle). It can also be given as an infusion through a drip into a vein. Your healthcare provider will decide the dose, route of administration, and duration of the treatment based on your health condition and other factors. Do not self-administer the medicine.

  • Alpelisib

    Description

    This page contains brief details about the drug alpelisib, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

    Date of Approval

    Alpelisib is an anticancer medication which was approved for its medical use on 24th May 2019.

    Mechanism of Action of Alpelisib

    Alpelisib is a targeted drug therapy for cancer that comes under the class of kinase inhibitors. It acts against the mutation of PI3K genes. PI3K genes are abundant in hormone receptor positive and human epidermal growth factor receptor 2 (HER2) breast cancers. Alpelisib works by stopping the cell signalling of PI3K genes and inhibits the growth and spread of cancer cells. It is often administered in combination with other chemotherapy agents like Fulvestrant.

    Uses of Alpelisib

    Alpelisib Tablet has been developed to treat advanced and metastatic breast cancer in men and menopausal women who have stopped responding to other treatments. It is particularly effective against hormone receptor positive and human epidermal growth factor receptor 2 (HER2) breast cancers caused by mutation in the PIK3CA gene.

    Alpelisib Dosage available Alpelisib is available as a film-coated tablets in the doses 150mg, 200mg, 200+50mg. Swallow the tablet whole with a glass of water without crushing or chewing them.

  • Triptorelin

    Description

    This page contains brief details about the drug triptorelin, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

    Date of Approval

    Triptorelin was approved for its medical use on 15th June 2000 by the US Food and Drug Administration. It is a medication that belongs to a class of drugs known as gonadotropin-releasing hormone (GnRH) analogs. It is primarily used in the field of reproductive medicine for the treatment of various conditions related to hormonal imbalance.

    Mechanism of Action of Triptorelin

    Triptorelin exerts its therapeutic effect by suppressing the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) through its action on the pituitary gland. This suppression leads to a decrease in the production of sex hormones, such as testosterone and estrogen. By reducing the levels of these hormones, this medication is beneficial in treating hormone-dependent conditions such as prostate cancer, breast cancer, and endometriosis.

    Uses of Triptorelin

    Triptorelin is used for the treatment of Prostate cancer in men, Early onset puberty in children 2 years of age and older (precocious puberty) and used to treat Endometriosis in females – a condition in which the tissue that normally lines the uterus—grows outside of it.

    Triptorelin Dosage available

    Triptorelin is available as a vial for injection in the doses 3.75mg, 11.25mg and 22.5mg.  It is administered as an intramuscular injection into either of the buttocks. Triptorelin is typically administered via injection, either subcutaneously (under the skin) or intramuscularly (into the muscle). The specific dosing and frequency of administration will depend on the individual’s condition being treated and their response to the medication. It is important to follow the healthcare professional’s instructions regarding the administration technique and schedule.

  • Oxaliplatin

    Description

    This page contains brief details about the drug oxaliplatin, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

    Date of Approval

    Oxaliplatin is an anti-cancer drug that belongs to the platinum coordination complexes and alkylating agent approved for its medical use in treating advanced colorectal cancer on  January 9, 2004.

    Mechanism of Action of Oxaliplatin

    Like other alkylating agents, oxaliplatin interferes with the development of DNA in a cancer cell. It stops cells from growing and multiplying and kills them. This helps to treat cancer which is caused by cells rapidly growing and dividing out of control.

    Uses of Oxaliplatin

    Oxaliplatin is indicated to treat adults with stage III colon cancer after surgery to remove the tumor. It is used with other anti-cancer medicines called 5-fluorouracil (5-FU) and leucovorin (LV) to treat adults with advanced colon or rectal cancer (colorectal cancer). It is also used as a combination therapy for Mantle cell lymphoma and Non-Hodgkin’s lymphoma ( a type of cancer that affects your lymphatic system, which is part of the body’s germ-fighting immune system). In combination with 5-fluorouracil and leucovorin, oxaliplatin is used as a second-line therapy to treat advanced or metastatic pancreatic cancer.

    Oxaliplatin Dosage available

    Oxaliplatin is given to you intravenously (IV) through your veins. The drug will be administered by a healthcare professional. Your physician will decide on the dose for administration based on the severity of the disease, weight, and height.  Some medicines may be given to you before oxaliplatin to help prevent nausea and vomiting.

  • Vinorelbine

    Description

    This page contains brief details about the drug vinorelbine, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

    Date of Approval

    Vinorelbine is a chemotherapy medication that was approved to be used in 1994.

    Mechanism of Action of Vinorelbine

    Vinorelbine works by inhibiting the microtubule structures within the cell. Microtubule structures help cancer cells to divide and multiply. Inhibition of these structures slows the growth and multiplication of cancer cells.

    Uses of Vinorelbine

    Non-small cell lung cancer (NSCLC)

    Breast cancer

    Vinorelbine Dosage available

    Vinorelbine is available as solution for infusion in two doses of 10mg and 50mg.

  • Methotrexate

    Description

    This page contains brief details about the drug methotrexate, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

    Date of Approval

    Methotrexate is an anti-metabolite and immunosuppressant drug. The FDA approved this for its medical use on 26th February 1999.

    Mechanism of Action of Methotrexate

    Methotrexate inhibits dihydrofolic acid reductase. Therefore, methotrexate interferes with DNA synthesis, repair, and cellular replication. Actively proliferating tissues such as malignant cells, bone marrow, fetal cells, buccal and intestinal mucosa, and urinary bladder cells are, in general, more sensitive to this medicine. Blocking these slows down how fast cancer cells grow and spread. In treating rheumatoid arthritis, methotrexate is thought to stop or reduce inflammation in the joints by altering the body’s defense mechanism in the immune system.

    Uses of Methotrexate

    It treats certain types of cancer, such as acute lymphocytic leukemia (ALL), meningeal leukemia, non-hodgkin’s lymphoma, osteosarcoma, cutaneous T-cell lymphoma, breast cancer, and head and neck cancer in adults. It is also used to treat severe psoriasis in adults (a skin disease in which red, scaly patches form on some body areas). It is also indicated to treat rheumatoid arthritis in adults.

    Methotrexate Dosage available

    Methotrexate is available as an injection and tablet. Always use this medicine as exactly prescribed by your doctor. Depending on the condition being treated, your physician decides the dose, dosage, and frequency of this injection. Methotrexate is injected into a vein (intravenously) or into muscle (intramuscularly). Do not self-administer this medicine. If you are prescribed with tablets, do not chew, crush or dissolve the tablets. The score line is only there to help you break the tablet if you have difficulty swallowing it whole.  Swallow the tablets whole with water.

  • Megestrol

    Description

    This page contains brief details about the drug megestrol, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

    Date of Approval

    Megestrol is an anticancer, antianorexia and anticachectic medication that was approved for its medical use in September 1993.

    Mechanism of Action of Megestrol

    Megestrol is an anticancer agent that belongs to the class of progestogens. It is a synthetic form of the naturally occurring female hormone progesterone. The exact mechanism of action is unknown, although it is said that Megestrol works through progestin-inducing mechanism and stimulates cell maturation by binding to the progesterone receptors.

    Uses of Megestrol

    Megestrol Tablet has been developed to treat hormone-dependent cancer like endometrial and breast cancer. Its off-label indications include treatment of cancer-related loss of appetite (anorexia) and muscle loss (cachexia).

    Megestrol Dosage available

    Megestrol is available as a tablet in doses 40mg and 160mg. The initial dose is 40mg four times a day and the maximum dosage is 800mg. The dosage and frequency vary according to the type of cancer.