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Category: Breast Cancer
Goserelin Acetate
Description
This page contains brief details about the drug goserelin acetate, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Goserelin Acetate is a gonadotropin-releasing hormone agonist. Goserelin Acetate 3.6mg implant was approved in 1989 whereas Goserelin Acetate 10.8mg was approved in 1996.
Mechanism of Action of Goserelin Acetate
Goserelin Acetate is a synthetic analogue of gonadotropin releasing hormone that binds to the gonadotropin receptors of pituitary gland. It lowers the androgen and testosterone levels in men and oestrogen levels in women. It is prescribed in combination with androgen antagonist like flutamide to prevent the initial flare up of tumor.
Uses of Goserelin Acetate
Goserelin Acetate Injection is an anticancer medication indicated for the palliative treatment of Advanced prostate cancer and breast cancer. It is also indicated as an endometrial thinning agent in uterine bleeding and for the management of endometriosis.
Goserelin Acetate Dosage available
Goserelin Acetate is available as a prefilled syringe indicated as an implant in the doses 3.6mg, and 10.8mg. It is administered through subcutaneous route.
Triptorelin
Description
This page contains brief details about the drug triptorelin, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Triptorelin was approved for its medical use on 15th June 2000 by the US Food and Drug Administration. It is a medication that belongs to a class of drugs known as gonadotropin-releasing hormone (GnRH) analogs. It is primarily used in the field of reproductive medicine for the treatment of various conditions related to hormonal imbalance.
Mechanism of Action of Triptorelin
Triptorelin exerts its therapeutic effect by suppressing the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) through its action on the pituitary gland. This suppression leads to a decrease in the production of sex hormones, such as testosterone and estrogen. By reducing the levels of these hormones, this medication is beneficial in treating hormone-dependent conditions such as prostate cancer, breast cancer, and endometriosis.
Uses of Triptorelin
Triptorelin is used for the treatment of Prostate cancer in men, Early onset puberty in children 2 years of age and older (precocious puberty) and used to treat Endometriosis in females – a condition in which the tissue that normally lines the uterus—grows outside of it.
Triptorelin Dosage available
Triptorelin is available as a vial for injection in the doses 3.75mg, 11.25mg and 22.5mg. It is administered as an intramuscular injection into either of the buttocks. Triptorelin is typically administered via injection, either subcutaneously (under the skin) or intramuscularly (into the muscle). The specific dosing and frequency of administration will depend on the individual’s condition being treated and their response to the medication. It is important to follow the healthcare professional’s instructions regarding the administration technique and schedule.
Vinorelbine
Description
This page contains brief details about the drug vinorelbine, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Vinorelbine is a chemotherapy medication that was approved to be used in 1994.
Mechanism of Action of Vinorelbine
Vinorelbine works by inhibiting the microtubule structures within the cell. Microtubule structures help cancer cells to divide and multiply. Inhibition of these structures slows the growth and multiplication of cancer cells.
Uses of Vinorelbine
Non-small cell lung cancer (NSCLC)
Breast cancer
Vinorelbine Dosage available
Vinorelbine is available as solution for infusion in two doses of 10mg and 50mg.
Methotrexate
Description
This page contains brief details about the drug methotrexate, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Methotrexate is an anti-metabolite and immunosuppressant drug. The FDA approved this for its medical use on 26th February 1999.
Mechanism of Action of Methotrexate
Methotrexate inhibits dihydrofolic acid reductase. Therefore, methotrexate interferes with DNA synthesis, repair, and cellular replication. Actively proliferating tissues such as malignant cells, bone marrow, fetal cells, buccal and intestinal mucosa, and urinary bladder cells are, in general, more sensitive to this medicine. Blocking these slows down how fast cancer cells grow and spread. In treating rheumatoid arthritis, methotrexate is thought to stop or reduce inflammation in the joints by altering the body’s defense mechanism in the immune system.
Uses of Methotrexate
It treats certain types of cancer, such as acute lymphocytic leukemia (ALL), meningeal leukemia, non-hodgkin’s lymphoma, osteosarcoma, cutaneous T-cell lymphoma, breast cancer, and head and neck cancer in adults. It is also used to treat severe psoriasis in adults (a skin disease in which red, scaly patches form on some body areas). It is also indicated to treat rheumatoid arthritis in adults.
Methotrexate Dosage available
Methotrexate is available as an injection and tablet. Always use this medicine as exactly prescribed by your doctor. Depending on the condition being treated, your physician decides the dose, dosage, and frequency of this injection. Methotrexate is injected into a vein (intravenously) or into muscle (intramuscularly). Do not self-administer this medicine. If you are prescribed with tablets, do not chew, crush or dissolve the tablets. The score line is only there to help you break the tablet if you have difficulty swallowing it whole. Swallow the tablets whole with water.
Megestrol
Description
This page contains brief details about the drug megestrol, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Megestrol is an anticancer, antianorexia and anticachectic medication that was approved for its medical use in September 1993.
Mechanism of Action of Megestrol
Megestrol is an anticancer agent that belongs to the class of progestogens. It is a synthetic form of the naturally occurring female hormone progesterone. The exact mechanism of action is unknown, although it is said that Megestrol works through progestin-inducing mechanism and stimulates cell maturation by binding to the progesterone receptors.
Uses of Megestrol
Megestrol Tablet has been developed to treat hormone-dependent cancer like endometrial and breast cancer. Its off-label indications include treatment of cancer-related loss of appetite (anorexia) and muscle loss (cachexia).
Megestrol Dosage available
Megestrol is available as a tablet in doses 40mg and 160mg. The initial dose is 40mg four times a day and the maximum dosage is 800mg. The dosage and frequency vary according to the type of cancer.
Ribociclib
Description
This page contains brief details about the drug ribociclib, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Ribociclib is an anticancer medication containing the active ingredient ribociclib. Cancer is a condition in which cells multiply uncontrolled and abnormally. It is used in women to treat a type of breast cancer (hormone receptor-positive, HER2-negative breast cancer) that is locally advanced or has spread to other parts of the body. This medication is given in combination with other medications. It can also be used to treat endometrial cancer in combination with other drugs. It works by inhibiting the activity of certain proteins, which regulate cell growth and division. By blocking these proteins, it can slow down or stop the growth of cancer cells. It is not recommended for adolescents and children under 18 years of age.
Ribociclib was developed by Novartis Pharmaceuticals and was approved by the U.S. Food and Drug Administration (FDA) on 13 March 2017. It was initially approved for use in combination with an aromatase inhibitor as initial endocrine-based therapy for postmenopausal women with hormone receptor-positive, HER2-negative advanced, or metastatic breast cancer. Before taking this medication, it is vital to inform your doctor if you have any signs of infections (fever, mouth ulcers, or sore throat), liver disorders, heart disorders, or if you are allergic to peanut or soya. You should not drink grapefruit juice or eat grapefruits during the treatment with this tablet. It should not be used in persons with a known hypersensitivity or allergy to Kryxana 200 mg Tablet or any of its components.
Mechanism of Action of Ribociclib
Ribociclib works by inhibiting the activity of two proteins called CDK4 and CDK6, which regulate cell growth and division. By blocking these proteins, Ribociclib can slow down or stop the growth of cancer cells.
Uses of Ribociclib
Ribociclib is a medication used to treat certain types of breast cancer. Ribociclib is used in combination with other anticancer medications to treat advanced or metastatic (cancer that can spread to other regions of the body) breast cancer. It can also be used in combination with fulvestrant for women who have gone through menopause and have metastatic breast cancer.
Ribociclib Dosage available
Ribociclib is usually taken orally, with or without food. The tablets should be swallowed whole with a glass of water and not crushed, chewed or broken. The dosage and frequency of Ribociclib will depend on a variety of factors, including the patient’s age, weight, overall health, and the type and stage of cancer being treated. It’s important to follow the dosing instructions provided by a healthcare provider, and not to adjust the dosage or frequency without consulting with them first.
Epirubicin
Description
This page contains brief details about the drug epirubicin, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Epirubicin is an antineoplastic drug that belongs to the class anthracyclines. FDA approved epirubicin on November 15, 2006, for the treatment of breast cancer, stomach, and bowel cancer, ovarian cancer, and lung cancer.
Mechanism of Action of Epirubicin
Epirubicin inhibits DNA, RNA, and protein synthesis by exerting cytotoxic activity. It works by slowing or stopping the growth of the cancer cells. This medicine helps to selectively kill the cancer cells rather than the normal, healthy cells.
Uses of Epirubicin
Epirubicin is an intravenously administered drug. This medicine is used as adjuvant therapy in combination with other medications to treat breast cancer in patients who have had surgery to remove the tumor. It is also useful in treating breast, ovaries, stomach, bowel, and lung cancers. In addition, this medicine is also used to treat cancers of the blood-forming tissues, such as malignant lymphomas, leukemias, and multiple myeloma.
Epirubicin Dosage available The drug should be administered only by healthcare professionals experienced with cancer chemotherapy. Your physician will determine the dose and frequency of administration based on the type of cancer and severity of the disease. The medicine will be given as an infusion into a vein. Do not self-administer the injection.
Denosumab
Description
This page contains brief details about the drug denosumab, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
The U.S. FDA approved Denosumab for the first time on June 1, 2010, to treat postmenopausal women with osteoporosis at high risk for fracture.
Mechanism of Action of Denosumab
Osteoclast breaks the tissues in the bones and releases calcium into the blood. This process is called bone resorption. Denosumab acts by inhibiting osteoclast formation, thereby decreasing bone resorption and increasing bone mass and strength.
Uses of Denosumab
Osteoporosis in women postmenopause who are at high risk of fracture
Men with osteoporosis who are at increased risk of fracture
Bone loss in men due to reduced levels of testosterone caused as a result of prostate cancer surgery or treatment with medications
Osteoporosis in patients with a high risk of fracture due to long-term treatment with glucocorticoids.
And increase bone mass in women at high risk of fracture due to adjuvant aromatase inhibitor therapy for breast cancer.
Denosumab Dosage available
Denosumab is to be administered by a healthcare provider. It is injected subcutaneously under the skin of stomach, upper thigh or upper arm. Denosumab is to be given once every six months.
Vinblastine
Description
This page contains brief details about the drug vinblastine, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Vinblastine is an anticancer drug that belongs to the category of medicines known as mitotic inhibitors. It was approved by the U.S. FDA in the year 1962 to treat Hodgkin’s and non-Hodgkin’s lymphoma.
Mechanism of Action of Vinblastine
It works by disrupting the formation of microtubules in cells. Microtubules are structures that help to support and shape cells, as well as transport molecules within cells. In cancer cells, microtubules play a key role in cell division and growth. By interfering with microtubule formation, this drug disrupts the ability of cancer cells to divide and grow, ultimately leading to their death.
Uses of Vinblastine
Vinblastine is used to treat Hodgkin’s and non-Hodgkin’s lymphoma, testicular cancer, breast cancer, and kaposi’s sarcoma.
Vinblastine Dosage available
The medicine will be administered to you by a healthcare professional in a hospital setting. Vinblastine is given as an injection into a vein (intravenous infusion) over a period of 30 minutes, once a day for up to 5 days. The dose, route of administration, and frequency will be decided by your doctor based on your disease condition and other factors.