treatmentoptions4u.com

Category: Colon

  • Oxaliplatin

    Description

    This page contains brief details about the drug oxaliplatin, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

    Date of Approval

    Oxaliplatin is an anti-cancer drug that belongs to the platinum coordination complexes and alkylating agent approved for its medical use in treating advanced colorectal cancer on  January 9, 2004.

    Mechanism of Action of Oxaliplatin

    Like other alkylating agents, oxaliplatin interferes with the development of DNA in a cancer cell. It stops cells from growing and multiplying and kills them. This helps to treat cancer which is caused by cells rapidly growing and dividing out of control.

    Uses of Oxaliplatin

    Oxaliplatin is indicated to treat adults with stage III colon cancer after surgery to remove the tumor. It is used with other anti-cancer medicines called 5-fluorouracil (5-FU) and leucovorin (LV) to treat adults with advanced colon or rectal cancer (colorectal cancer). It is also used as a combination therapy for Mantle cell lymphoma and Non-Hodgkin’s lymphoma ( a type of cancer that affects your lymphatic system, which is part of the body’s germ-fighting immune system). In combination with 5-fluorouracil and leucovorin, oxaliplatin is used as a second-line therapy to treat advanced or metastatic pancreatic cancer.

    Oxaliplatin Dosage available

    Oxaliplatin is given to you intravenously (IV) through your veins. The drug will be administered by a healthcare professional. Your physician will decide on the dose for administration based on the severity of the disease, weight, and height.  Some medicines may be given to you before oxaliplatin to help prevent nausea and vomiting.

  • Irinotecan

    Description

    This page contains brief details about the drug irinotecan, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

    Date of Approval

    Irinotecan is an anti-cancer drug that belongs to the camptothecin analogs. The FDA approved it on August 24, 2004, to treat colon and rectum metastatic carcinoma.

    Mechanism of Action of Irinotecan

    Irinotecan works by converting its active metabolite with the help of liver enzymes and inhibits the Topoisomerase I enzyme. This causes damage to the DNA synthesis and its replication, thus preventing the cancer cells from growing and spreading.

    Uses of Irinotecan

    Irinotecan is a topoisomerase enzyme inhibitor used as a first-line therapy in combination with other anti-cancer medications to treat colon and rectum cancers and extensive-stage non-small cell lung cancer. It is also indicated to treat gastric cancers. Irinotecan is currently under investigation to treat ovarian and cervical cancer.

    Irinotecan Dosage available

    Irinotecan is a prescription drug available as an injection to be administered for over 90 minutes intravenously (into the vein), followed by other chemotherapeutic drugs. The drug will be prescribed and administered by the healthcare professional. It is normally administered no more than once a week, according to the schedule, on which days you receive irinotecan and on which days you dont receive the medication. Your doctor will determine the optimum schedule for you. Antiemetic medications may be given priorly to prevent nausea and vomiting associated with the treatment.

  • Capecitabine+Cyclophosphamide

    Description

    This page contains brief details about the drug capecitabine and cyclophosphamide, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

    Date of Approval

    Capecitabine and cyclophosphamide is an anticancer drug that belongs to the category of medicines known as antimetabolite and alkylating agents. It was approved in April 1998 to treat Metastatic colorectal cancer.

    Mechanism of Action of Capecitabine+Cyclophosphamide

    It gets converted into its active form called fluorouracil and interferes with cell signalling, ultimately preventing the multiplication of cancer cells. Capecitabine and cyclophosphamide is prescribed alone and also in combination with other anticancer medications like Docetaxel and Oxaliplatin.

    Uses of Capecitabine+Cyclophosphamide

    Capecitabine and cyclophosphamide has been developed as a first-line agent to treat advanced and metastatic colorectal cancer and also indicated as an adjunct treatment for stage III colon cancer after the failure of Irinotecan therapy. Capecitabine is also prescribed to treat breast cancer after the failure of taxane-based therapy.

    Capecitabine+Cyclophosphamide Dosage available

    Capecitabine and cyclophosphamide is available in the form of 500mg tablets. Swallow a tablet with water 30 minutes after food. If you have difficulty swallowing the tablet, seek help from a healthcare provider specialized in the usage of cytotoxic medications to crush or cut the tablet. The accurate dose will be calculated by your healthcare provider and the recommended dosing cycle is twice a day for 2 weeks followed by a 7-days rest period.

  • Capecitabine

  • Fluorouracil

    Description

    This page contains brief details about the drug fluorouracil, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

    Date of Approval

    Fluorouracil contains the active ingredient Fluorouracil. It belongs to a class of drugs called antimetabolites, which interfere with the genetic material (DNA and RNA) synthesis of rapidly dividing cancer cells, leading to their death. This medication is commonly used to treat breast, colorectal, stomach, esophagus, and pancreatic cancers. It can be administered in different ways, including through injection or as a cream.

    Fluorouracil (5-fluorouracil or 5-FU) was first approved by the US Food and Drug Administration (FDA) in 1959 for treating colon and rectal cancer. Since then, it has been approved for treating other types of cancer, including breast, stomach, and pancreatic cancer. The drug is also approved in many other countries around the world. Over the years, many studies proved the effectiveness of fluorouracil in combination with other cancer treatments, and the drug continues to be an important chemotherapy medication for cancer patients.

    Mechanism of Action of Fluorouracil

    Fluorouracil work by interfering with the DNA and RNA synthesis of rapidly dividing cancer cells, leading to their death. It is an antimetabolite chemotherapy drug that mimics the structure of normal DNA and RNA building blocks. Still, its incorporation into DNA and RNA leads to errors in formation and causes damage to the DNA and RNA strands.

    Uses of Fluorouracil

    Fluorouracil is a chemotherapy medication commonly used to treat different types of cancer, including breast, colon, rectal, stomach, and pancreatic cancers. It works by interfering with the growth and division of cancer cells, ultimately causing them to die.

    Fluorouracil Dosage available

    Fluorouracil is a medication typically administered under a healthcare provider’s supervision, usually in a hospital or clinic setting. The method of administration can vary depending on the type of cancer and the individual patient’s condition. The injection can be given in a vein (intravenous) or muscle (intramuscular) injection. If a patient misses a scheduled dose, they should contact their healthcare provider immediately to determine the next steps. Sometimes, the missed dose may be rescheduled, or a new treatment plan may be recommended. It is important to follow the healthcare provider’s instructions closely and not make any changes to the treatment plan without first consulting with them. Patients should never take a double dose to make up for a missed dose, as this can increase the risk of side effects and toxicity.