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Category: Head and Neck Cancer
Methotrexate
Description
This page contains brief details about the drug methotrexate, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Methotrexate is an anti-metabolite and immunosuppressant drug. The FDA approved this for its medical use on 26th February 1999.
Mechanism of Action of Methotrexate
Methotrexate inhibits dihydrofolic acid reductase. Therefore, methotrexate interferes with DNA synthesis, repair, and cellular replication. Actively proliferating tissues such as malignant cells, bone marrow, fetal cells, buccal and intestinal mucosa, and urinary bladder cells are, in general, more sensitive to this medicine. Blocking these slows down how fast cancer cells grow and spread. In treating rheumatoid arthritis, methotrexate is thought to stop or reduce inflammation in the joints by altering the body’s defense mechanism in the immune system.
Uses of Methotrexate
It treats certain types of cancer, such as acute lymphocytic leukemia (ALL), meningeal leukemia, non-hodgkin’s lymphoma, osteosarcoma, cutaneous T-cell lymphoma, breast cancer, and head and neck cancer in adults. It is also used to treat severe psoriasis in adults (a skin disease in which red, scaly patches form on some body areas). It is also indicated to treat rheumatoid arthritis in adults.
Methotrexate Dosage available
Methotrexate is available as an injection and tablet. Always use this medicine as exactly prescribed by your doctor. Depending on the condition being treated, your physician decides the dose, dosage, and frequency of this injection. Methotrexate is injected into a vein (intravenously) or into muscle (intramuscularly). Do not self-administer this medicine. If you are prescribed with tablets, do not chew, crush or dissolve the tablets. The score line is only there to help you break the tablet if you have difficulty swallowing it whole. Swallow the tablets whole with water.
Docetaxel
Description
This page contains brief details about the drug docetaxel, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Docetaxel is a chemotherapy medication that was approved to be used for its medical use on 19th May 2004.
Mechanism of Action of Docetaxel
Docetaxel works by inhibiting the microtubule structures found in the cells. These microtubules help the cancer cells in proliferating. Hence, inhibition of these structures aids in slowing down the growth of the cancer cells.
Uses of Docetaxel
Docetaxel is indicated for treating different types of cancers, which include the following, non-small cell lung cancer, breast cancer, prostate cancer, stomach cancer and head and neck cancer.
Docetaxel Dosage available
Docetaxel concentrate for solution for infusion (injections) is available in three doses of 20mg, 80mg and 120mg.
Nimotuzumab
Description
This page contains brief details about the drug nimotuzumab, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Nimotuzumab consists of the active Nimotuzumab. It is a monoclonal antibody used in cancer treatment. It has been approved for the treatment of head and neck cancer, as well as for certain types of brain cancer. This medication is typically used with other cancer treatments, such as chemotherapy and radiation therapy.
There are no absolute contraindications to Nimotuzumab, but there are some precautions and potential contraindications to consider. For example, patients with a history of severe allergic reactions or hypersensitivity to it or its components should not receive the medication. Additionally, patients with certain medical conditions, such as severe liver or kidney disease, may need to be monitored closely or have their dosages adjusted.
Mechanism of Action of Nimotuzumab
Nimotuzumab is primarily focused on its ability to target and bind to the epidermal growth factor receptor (EGFR) found on many cancer cells. By doing so, it can block the growth and spread of cancer cells, ultimately leading to improved outcomes for cancer patients. One of the advantages of this medication is its targeted therapy approach, which allows it to target cancer cells while minimizing damage to healthy cells specifically. This can help to reduce side effects and improve the overall quality of life for cancer patients undergoing treatment.
Uses of Nimotuzumab
Nimotuzumab is used in the treatment of several types of cancer, including head and neck cancer and certain types of brain cancer, such as glioma and glioblastoma. It is often combined with other cancer treatments, such as chemotherapy and radiation therapy, to improve overall and disease-free outcomes.
Nimotuzumab Dosage available
Nimotuzumab is an injectable medication that a healthcare professional administers. It is typically given as an intravenous injection. The dose and frequency will depend on the type of cancer being treated, the patient’s overall health, and other medications the patient may be taking. If you miss a dose, contact your healthcare provider as soon as possible. Your healthcare provider may recommend rescheduling your next dose or adjusting your dosing schedule. Do not double the dose to make a missed dose.
Vincristine Sulphate
Description
This page contains brief details about the drug vincristine sulphate, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Vincristine sulphate is a chemotherapy medication containing the active constituent vincristine sulphate. It belongs to a class of drugs called vinca alkaloids, which inhibit the growth of cancer cells. This medication treats blood, head, breast, neck, kidney, bone, or lung cancers. It treats rhabdomyosarcoma (cancer that affects muscle tissue) and neuroblastoma (cancer that develops from immature nerve cells). It may also treat multiple myeloma (cancer of plasma cells), thyroid cancer, and a blood disorder known as idiopathic thrombocytopenic purpura (ITP). Cancer is a disorder in which cells multiply uncontrolled and abnormally.
Vincristine sulphate was first approved by the FDA in 1963 for treating acute lymphocytic leukemia (ALL). Since then, it has received additional approvals for treating other types of cancer. Like all chemotherapy drugs, it can cause side effects, such as nausea, vomiting, constipation, hair loss, and fatigue. Patients should discuss the potential benefits and risks of treatment with their doctor.
Mechanism of Action of Vincristine Sulphate
The therapeutic effect of vincristine sulphate inhibits the growth and spread of cancer cells. Vincristine sulphate disrupts the formation and function of microtubules, which are structures inside cells that help with cell division and movement. By interfering with microtubule function, this medication can prevent cancer cells from dividing and multiplying and can also cause them to die.
Uses of Vincristine Sulphate
Vincristine sulphate is used to treat various types of cancer, including blood cancers such as acute lymphocytic leukemia (ALL), head and neck cancers, breast cancer, kidney cancer, bone cancer, and lung cancer. It is also used to treat idiopathic thrombocytopenic purpura (a condition in which the immune system attacks and destroys platelets cells) and multiple myeloma (a type of blood cancer that affects plasma cells). In addition, this medication is used to treat rhabdomyosarcoma (cancer that forms in the body’s soft tissues) and neuroblastoma (cancer that develops in certain nerve cells). It may also be used to treat thyroid cancer.
Vincristine Sulphate Dosage available
A healthcare professional usually administers vincristine sulphate intravenous injection (IV) in a hospital or clinical setting. It should not be taken orally or applied topically to the skin. If you miss a dose, do not double the dose to make up for the missed one.