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Category: Prostate cancer
Goserelin Acetate
Description
This page contains brief details about the drug goserelin acetate, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Goserelin Acetate is a gonadotropin-releasing hormone agonist. Goserelin Acetate 3.6mg implant was approved in 1989 whereas Goserelin Acetate 10.8mg was approved in 1996.
Mechanism of Action of Goserelin Acetate
Goserelin Acetate is a synthetic analogue of gonadotropin releasing hormone that binds to the gonadotropin receptors of pituitary gland. It lowers the androgen and testosterone levels in men and oestrogen levels in women. It is prescribed in combination with androgen antagonist like flutamide to prevent the initial flare up of tumor.
Uses of Goserelin Acetate
Goserelin Acetate Injection is an anticancer medication indicated for the palliative treatment of Advanced prostate cancer and breast cancer. It is also indicated as an endometrial thinning agent in uterine bleeding and for the management of endometriosis.
Goserelin Acetate Dosage available
Goserelin Acetate is available as a prefilled syringe indicated as an implant in the doses 3.6mg, and 10.8mg. It is administered through subcutaneous route.
Triptorelin
Description
This page contains brief details about the drug triptorelin, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Triptorelin was approved for its medical use on 15th June 2000 by the US Food and Drug Administration. It is a medication that belongs to a class of drugs known as gonadotropin-releasing hormone (GnRH) analogs. It is primarily used in the field of reproductive medicine for the treatment of various conditions related to hormonal imbalance.
Mechanism of Action of Triptorelin
Triptorelin exerts its therapeutic effect by suppressing the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) through its action on the pituitary gland. This suppression leads to a decrease in the production of sex hormones, such as testosterone and estrogen. By reducing the levels of these hormones, this medication is beneficial in treating hormone-dependent conditions such as prostate cancer, breast cancer, and endometriosis.
Uses of Triptorelin
Triptorelin is used for the treatment of Prostate cancer in men, Early onset puberty in children 2 years of age and older (precocious puberty) and used to treat Endometriosis in females – a condition in which the tissue that normally lines the uterus—grows outside of it.
Triptorelin Dosage available
Triptorelin is available as a vial for injection in the doses 3.75mg, 11.25mg and 22.5mg. It is administered as an intramuscular injection into either of the buttocks. Triptorelin is typically administered via injection, either subcutaneously (under the skin) or intramuscularly (into the muscle). The specific dosing and frequency of administration will depend on the individual’s condition being treated and their response to the medication. It is important to follow the healthcare professional’s instructions regarding the administration technique and schedule.
Degarelix
Description
This page contains brief details about the drug degarelix, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Degarelix is an anticancer medication that was approved for its medical use on 24th December 2008.
Mechanism of Action of Degarelix
Degarelix Injection is a biological agent that acts as hormonal drug therapy in cancer treatment. It is the only antagonist of Androgen Deprivation Therapy that works instantly to reduce testosterone levels. Degarelix is a gonadotropin-releasing hormone agonist that binds to the gonadotropin receptors of the pituitary gland. It lowers the release of gonadotrophin and testosterone, eventually inhibiting the development of cancer cells. Degarelix is prescribed alone and also with other anti-androgen medications to treat hormonal cancer.
Uses of Degarelix
Degarelix Injection has been developed to treat advanced prostate cancer in adult men.
Degarelix Dosage available Degarelix is available as a vial for injection in doses 80mg and 120mg. It is intended for administration through the subcutaneous route. The recommended initial dose is 240mg given as two 120 mg injections and 80mg is injected every 28 days as a maintenance dose.
Docetaxel
Description
This page contains brief details about the drug docetaxel, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Docetaxel is a chemotherapy medication that was approved to be used for its medical use on 19th May 2004.
Mechanism of Action of Docetaxel
Docetaxel works by inhibiting the microtubule structures found in the cells. These microtubules help the cancer cells in proliferating. Hence, inhibition of these structures aids in slowing down the growth of the cancer cells.
Uses of Docetaxel
Docetaxel is indicated for treating different types of cancers, which include the following, non-small cell lung cancer, breast cancer, prostate cancer, stomach cancer and head and neck cancer.
Docetaxel Dosage available
Docetaxel concentrate for solution for infusion (injections) is available in three doses of 20mg, 80mg and 120mg.
Leuprolide Acetate
Description
This page contains brief details about the drug leuprolide acetate, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Leuprolide Acetate is a gonadotropin-releasing hormone (GnRH) agonist approved for its medical use on 9th April 1985.
Mechanism of Action of Leuprolide Acetate
Leuprolide Acetate Injection is a biological agent that acts as hormonal drug therapy in cancer treatment. It comes under the class of Gonadotropin-releasing hormone (GnRH) agonist. It stimulates the luteinizing hormone and follicle-stimulating hormone of the pituitary gland, resulting in high estrogen in females and high testosterone and dihydrotestosterone in males. With continuous use, the levels of these hormones fall, and the organs which depend on these hormones become inactive. It is often administered in combination with other medications to alleviate pain symptoms.
Uses of Leuprolide Acetate
Leuprolide Acetate Injection has been developed to treat solid tumors by injecting it directly into the bloodstream. Leuprolide Acetate Injection has been approved to treat several conditions such as prostate cancer, endometriosis, uterine fibroids and other hormonal conditions.
Leuprolide Acetate Dosage available
Leuprolide acetate Injection is available in different doses. This injection will be mostly administered by your doctor or nurse on your arm, thigh or abdomen after preparation. The site of injecting this medicine will be changed regularly. Your healthcare provider will administer this medicine once in three months.
Enzalutamide
Description
This page contains brief details about the drug enzalutamide, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Enzalutamide is an anticancer drug that belongs to the category of medicines known as antimetabolite. It was approved by the U.S. FDA on 31st of August 2012 to treat Prostate cancer.
Mechanism of Action of Enzalutamide
It works by inhibiting the active form of testosterone, called dihydrotestosterone. It selectively blocks the androgen receptors and disrupts the translocation of signals from the receptor to the cell. Thus, the androgen hormone does not bind to the androgen receptors and these androgen receptors do not interact with DNA. This blocks the functioning of cancer cells and reduces its multiplication.
Uses of Enzalutamide
Enzalutamide is prescribed to treat metastatic castration-resistant prostate cancer (mCRPC) and metastatic castration-sensitive prostate cancer (mCSPC).
Enzalutamide Dosage available
Enzalutamide is to be administered orally. This medication is to be swallowed as whole with water, without cutting, crushing or chewing. It can be taken with or without food.
Apalutamide
Description
This page contains brief details about the drug apalutamide, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Apalutamide is an anticancer drug in the androgen receptor inhibitors class of medications. The FDA approved the medicine for its medical use on September 17, 2019.
Mechanism of Action of Apalutamide
Apalutamide is a selective androgen receptor (AR) inhibitor that binds directly to the androgen receptor binding domain. It inhibits protein transportation in the nucleus, DNA binding, and AR-mediated transcription. Treatment with Apalutamide reduces cancer cell growth and increases cell death, resulting in effective anticancer activity.
Uses of Apalutamide
It is indicated for treating patients with certain types of prostate cancer whose cancer has spread to other parts of the body and still responds to a medical or surgical treatment that lowers testosterone (male reproductive hormone) or whose cancer has not spread to other parts of the body and no longer responds to a medical or surgical treatment that lowers testosterone.
Apalutamide Dosage available
Apalutamide is an orally administered drug. Take medicine as informed by your physician. It is generally taken with or without food once a day. Take the tablet at around the same time every day. Swallow the tablets whole; do not split, chew, or crush them. Do not stop taking Apalutamide without talking to your doctor.