Category: Infections

Description

This page contains brief details about the drug ampicillin,sulbactam, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Date of Approval

Ampicillin and Sulbactam is a combination antibiotic medication that contains two active ingredients, ampicillin and Sulbactam. It has been used for many years and has well-established safety profiles. They have been extensively studied and are considered safe and effective when prescribed. It is used in the treatment of various bacterial infections. Ampicillin is a penicillin-type antibiotic that works by inhibiting the growth of bacteria. It is effective against both Gram-positive and Gram-negative organisms. Sulbactam is a beta-lactamase inhibitor. Beta-lactamases are enzymes some bacteria produce that can break down certain antibiotics, including penicillins. Combining Sulbactam with ampicillin makes the medication more effective against bacteria that produce beta-lactamases. It received initial FDA approval for use in the United States on October 29, 1986.

Mechanism of Action of Ampicillin, Sulbactam

Ampicillin is a penicillin-type antibiotic that belongs to the beta-lactam class. It inhibits the synthesis of bacterial cell walls. Bacterial cell walls are essential for their survival and protection, and without a functional cell wall, bacteria cannot maintain their structure and integrity. Ampicillin interferes with the enzymes involved in synthesizing the bacterial cell wall, leading to its weakening and eventual lysis (breakdown). Sulbactam is a beta-lactamase inhibitor. Beta-lactamase is an enzyme certain bacteria produce to break down and inactivate beta-lactam antibiotics, including penicillins. Combining sulbactam with ampicillin makes the medication effective against bacteria that produce beta-lactamases. Sulbactam inhibits the action of these enzymes, preventing them from degrading ampicillin. This allows ampicillin to remain active and exert its antibacterial effect.

Uses of Ampicillin, Sulbactam

The combination of ampicillin and sulbactam is often used to treat various infections, including respiratory tract infections, urinary tract infections, skin and soft tissue infections, intra-abdominal infections, and gynecological infections. It is also sometimes used as empiric therapy for suspected mixed infections or when the specific bacteria causing the infection are unknown.

Ampicillin, Sulbactam Dosage available Ampicillin and Sulbactam is typically administered by a healthcare professional. It is usually given intravenously (IV) as an infusion or injection. The healthcare provider will determine the dosage and duration of treatment based on the specific infection and individual factors.