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Dacarbazine
Description
This page contains brief details about the drug dacarbazine, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Dacarbazine is an anticancer drug that belongs to the category of medicines known as alkylating agents. It was approved in May 1975 to treat Metastatic malignant melanoma.
Mechanism of Action of Dacarbazine
It is a type of alkylating agent, which works majorly through the process of alkylation. It enters the cancer cells after getting activated by the liver and inhibits DNA synthesis. This process disrupts the normal cell cycle and DNA function, leading to arrest in cancer cell growth and multiplication.
Uses of Dacarbazine
Dacarbazine has been developed as a first-line agent to treat advanced and metastatic malignant melanoma. This drug is also prescribed to treat Hodgkin’s disease.
Dacarbazine Dosage available
Dacarbazine will be administered to you by a healthcare professional in a hospital setting. This injection will be given intravenously into a vein in your arm or hand. Do not self-administer this medicine. The specific dose and schedule of administration depend on the type and stage of the cancer being treated. This injection is usually given about 30 minutes before you receive your anti-cancer medicine (chemotherapy). During the infusion, you will be monitored for any side effects or reactions to the medication. It is important to get the dose at the scheduled time. If you missed the schedule, contact your doctor and reschedule the dose.
Crizotinib
Description
This page contains brief details about the drug crizotinib, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
The U.S. FDA-approved Crizotinib to treat people with ALK-positive NSCLC in the year of 2011.
Mechanism of Action of Crizotinib
Crizotinib Capsule is a biological agent that acts as targeted drug therapy in cancer treatment. It is classified as a tyrosine kinase inhibitor. Anaplastic lymphoma kinase and ROS1 are two prominent genes that result in non-small cell lung cancer by undergoing mutation. Crizotinib acts by inhibiting these genes and stops the growth and development of cancer cells by shrinking them.
Uses of Crizotinib
Crizotinib capsule is indicated to treat the advanced stage of lung cancer as an initial treatment and is also recommended when other anticancer treatments did not work. It is prescribed to treat ALK-positive non-small cell lung cancer (NSCLC)
Crizotinib Dosage available
Crizotinib is available in 200mg and 250mg capsules. The recommended dose is 250mg twice daily, preferably one capsule each in the morning and evening. It is advisable to take this medicine at the same time each day with or without food. Swallow the capsule and do not crush, open, or dissolve them.
Colistimethate Sodium
Description
This page contains brief details about the drug colistimethate sodium, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Colistimethate Sodium is a polymixin antibiotic agent. Initially, Colistin was discovered in 1947, and FDA approved Colistimethate sodium was approved for medical use in 1970
Mechanism of Action of Colistimethate Sodium
Colistimethate sodium, a polypeptide antibiotic, penetrates and disrupts the bacterial cell membrane of susceptible strains of aerobic gram-negative bacteria. It works by killing bacteria
Uses of Colistimethate Sodium
Colistimethate Sodium is used to treat certain types of infections caused by bacteria. This medicine is commonly used when other antibiotics are not suitable. It is sometimes given as an inhalation to treat chronic chest infections in patients with cystic fibrosis. This medicine is used when these infections are caused by specific bacteria called Pseudomonas aeruginosa.
Colistimethate Sodium Dosage available
A doctor or nurse in a hospital or clinic setting will give it to you. Depending on the reason, the drug may be given by fast or slow injection into a vein. Do not self-administer the injection. Your doctor will decide the dose and duration of the treatment based on your disease severity, body weight, and other factors.
Cisplatin
Description
This page contains brief details about the drug cisplatin, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
The U.S. FDA approved Cisplatin as an anticancer medication to treat a certain type of cancer on 19th December 1978.
Mechanism of Action of Cisplatin
Cisplatin belongs to the medication class known as an alkylating agent. It is an anti-cancer medicine that contains the active ingredient Cisplatin. Cisplatin works by stopping the growth and division of cancer cells. It does this by binding to the DNA in the cancer cells and preventing them from replicating.
Uses of Cisplatin
Cisplatin is used to treat testicular tumors, ovarian tumors, bladder tumors, lung cancer, cervical cancer, head and neck epithelial tumors, and. This medicine can prevent the proliferation of cancer cells and prevents cell division which ultimately leads to cell death.
Cisplatin Dosage available Cisplatin injection is administered as an intravenous infusion into the vein. If this injection is recommended for you, it will be given by a healthcare professional. Do not self-administer. Your physician will choose the dosage and administration frequency based on the medical condition because it differs for each person.
Bleomycin
Description
This page contains brief details about the drug bleomycin, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Bleomycin consists of the active ingredient Bleomycin. It belongs to a group of drugs known as antineoplastic antibiotics. It is commonly used in cancer treatment to slow or stop the growth of cancer cells. It treats lymph node cancers (Hodgkin’s and non-Hodgkin’s lymphoma), head and neck cancer, and cancer in external genitalia. It either be used alone or with radiotherapy and chemotherapy treatment. This injection is also beneficial to prevent and treat the fluid accumulation in the lungs due to cancer.
Bleomycin was first approved by the US Food and Drug Administration (FDA) in 1973 for the treatment of several types of cancer, including Hodgkin’s lymphoma, non-Hodgkin’s lymphoma, squamous cell carcinoma, and testicular cancer. It is also used off-label for treating other types of cancers, such as cervical cancer and melanoma. Bleomycin is a glycopeptide antibiotic that was first isolated from a bacteria named Streptomyces verticillus in 1966.
Mechanism of Action of Bleomycin
Bleomycin is inhibiting cancer cell growth and proliferation. By interfering with DNA replication and transcription, it can slow or stop the growth of cancer cells, leading to their destruction. This effect is particularly important in the treatment of Hodgkin’s lymphoma, non-Hodgkin’s lymphoma, testicular cancer, and some types of lung cancer, where rapid cell growth and division are characteristic features of the disease. Overall, it can help to shrink tumors and improve symptoms in cancer patients.
Uses of Bleomycin
Bleomycin is primarily used to treat several types of cancer, including Hodgkin’s lymphoma, non-Hodgkin’s lymphoma, squamous cell carcinoma, and testicular cancer. It is also used off-label for treating other types of cancers, such as cervical cancer and melanoma. As part of a chemotherapy regimen, it is often used with other drugs to increase its effectiveness. In some cases, it may also be used as a single agent for treating certain cancers. It is particularly effective in the treatment of testicular cancer.
Bleomycin Dosage available
Bleomycin is administered through injection by a healthcare provider in a hospital or clinical setting. The dosage and frequency of administration will vary depending on the type of cancer being treated, the patient’s age and weight, and other factors. It should not be taken orally, as it is not absorbed well through the gastrointestinal tract and may cause serious side effects if ingested.
During treatment, patients should follow their healthcare provider’s instructions closely and attend all scheduled appointments to monitor their condition and response to treatment. If a dose is missed, patients should contact their healthcare provider immediately for instructions on when to take the next dose. It is important not to double the dose to make up for a missed one.
Chlorambucil
Description
This page contains brief details about the drug chlorambucil, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Chlorambucil is an anticancer drug that belongs to the class of medications called alkylating agents. FDA approved it initially on November 1, 2013, for treating some types of cancer and certain blood problems.
Mechanism of Action of Chlorambucil
Chlorambucil is an aromatic nitrogen mustard derivative and alkylating agent that interferes with DNA replication. It also induces cellular apoptosis by the accumulation of protein cytosolic p53 and activation of BAX, an cell death promoter. It works by reducing the number of abnormal cells your body makes.
Uses of Chlorambucil
Chlorambucil is available as a tablet. It is used to treat Hodgkin’s disease and non-hodgkin’s lymphoma (cancers formed from cells of the lymphatic system). It is also indicated to treat chronic lymphocytic leukemia (A type of WBC cancer, where the bone marrow produces a large number of abnormal cells) and Waldenstrom’s macroglobulinemia (A rare lymphoma associated with an uncontrolled increase of B-cells, a type of white blood cell, resulting in the release of an abnormal protein into the blood.)
Chlorambucil Dosage available
Chlorambucil is available as an oral prescription drug. It is available in two doses 200mg and 400mg. Your doctor will decide the dose, and duration of the therapy based on your disease status, severity, and other factors such as body weight, other disease conditions, and age. Always take this medicine as prescribed by your doctor. Take the tablet daily on an empty stomach at least one hour before meals or three hours after meals. Do not break, chew, crush, or break the tablet. Swallow the whole tablet with water.
Busulfan
Description
This page contains brief details about the drug busulfan, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Busulfan is an anti-cancer medication that was approved to be used on 2 April 1999.
Mechanism of Action of Busulfan
Busulfan is an alkylating chemotherapeutic agent that works by interfering with the DNA replication process, which is necessary for the cells to divide. It stops tumor growth by inhibiting cell division.
Uses of Busulfan
Busulfan is used to treat
Hematopoietic progenitor cell transplantation
Chronic myelogenous leukemia
Polycythaemia vera (a type of cancer that causes an increase in red blood cells)
Thrombocythemia (increased number of platelets in the blood)
Myelofibrosis (type of blood cancer where scar tissues are formed in bone marrow)
Hemoglobinopathies (a genetic disorder that produces abnormal hemoglobin)
Brain Malignancies
Busulfan Dosage available
Busulfan is available as a tablet that is to be swallowed whole with water. The available dose is 2mg.
Busulfan is an injection that is to be given only under the supervision of a qualified healthcare professional. The available dose is 6omg.
Bosutinib
Description
This page contains brief details about the drug bosutinib, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Bosutinib is an anti-cancer medication that belongs to tyrosine kinase inhibitors. The drug was first approved in September 2012 for treating patients with chronic, accelerated, or blast-phase Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) who are resistant or can no longer benefit from other medications for CML. Later on, FDA approved bosutinib for the treatment of patients with newly-diagnosed chronic phase (CP) Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) in December 19, 2017.
Mechanism of Action of Bosutinib
The active role of bosutinib is to block the enzyme tyrosine kinase. Specifically, it blocks the action of certain enzymes found in white blood cells. The Bcr-Abl gene is an oncogene (cancer-causing gene) created from the fusion of the two genes; breakpoint-cluster (Bcr) gene and Abelson (Abl) tyrosine gene. This fusion results in the formation of the Philadelphia chromosome. The gene expresses a particular enzyme that promotes the progression of CML. They are involved in stimulating the cells to divide uncontrollably. By blocking the enzyme, bosutinib helps to control cell division, thereby controlling the growth and spread of the leukemia cells in CML.
Uses of Bosutinib
It is used to treat three stages of chronic myelogenous leukemia (CML) called ‘chronic phase’, ‘accelerated phase’, and ‘blast phase’ in patients who have already been treated with one or more tyrosine kinase inhibitors (medicines for CML which work in a similar way to Bosutinib) and became intolerant (no longer being benefited) to it. It is also used to treat newly-diagnosed chronic phase (CP) Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+ CML).
Bosutinib Dosage available
Bosutinib is available as oral tablets in 100 mg, 400 mg, and 500 mg. The drug will be prescribed by the healthcare professional. Your physician will decide on the dose and frequency based on the severity of the disease, weight, and height. For Newly-diagnosed chronic phase (Ph+) CML, 400 mg orally once daily with food will be prescribed initially. For managing Chronic, accelerated, or blast phase (Ph+) CML with resistance or intolerance to prior therapy, 500 mg orally once daily with food is given. The doctor may increase the dose up to 600 mg once a day or reduce it or interrupt treatment according to how the medicine works for you and based on the side effects.
Etoposide
Description
This page contains brief details about the drug etoposide, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
ETOPOSIDEThe U.S. FDA approved Etoposide as an anticancer medication to treat a certain type of cancer on 11th April 1983.
Mechanism of Action of Etoposide
Etoposide works by inhibiting the activity of topoisomerase II (essential for cell replication) and DNA synthesis, which will prevent cancer cells from growing and multiplying, ultimately leading to cell death.
Uses of Etoposide
Etoposide treats testicular, small-cell lung, acute myeloid leukemiaacute myeloid leukemia (blood cancer), Hodgkin’s and non-Hodgkin’s lymphoma, and ovarian cancer. This medicine can prevent the proliferation of cancer cells and prevents cell division which ultimately leads to cell death.
Etoposide Dosage available
It is an intravenous infusion drug that is injected through the veins. Your physician will choose the dosage and administration frequency based on your medical condition because it differs for each person.