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Amphotericin B
Description
This page contains brief details about the drug amphotericin b, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Amphotericin B is an antifungal antibiotic. FDA approved this medicine on 11th August 1997 for its medical use.
Mechanism of Action of Amphotericin B
Amphotericin B binds primarily to ergosterol in sensitive fungi cell membranes, causing membrane permeability changes that result in leakage of intracellular contents and cell death.
Uses of Amphotericin B
It is used to treat fungal infections of one or more deep body organs. It is also used to treat suspected fungal infections in patients with a raised temperature and neutropenia (reduced number of white blood cells). It is also indicated to treat visceral leishmaniasis, a disease caused by a parasite in certain people.
Amphotericin B Dosage available
A doctor or nurse in a hospital or clinic setting will give it to you. It is given as an intravenous infusion drip (into your vein). Do not self-administer the injection. Your doctor will decide the dose and duration of the treatment based on your disease severity, body weight, and other factors.
Liposomal Amphotericin B
Description
This page contains brief details about the drug liposomal amphotericin b, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Liposomal Amphotericin B is an antifungal antibiotic. FDA approved this medicine on 11th August 1997 for its medical use.
Mechanism of Action of Liposomal Amphotericin B
Liposomal Amphotericin B binds primarily to ergosterol in sensitive fungi cell membranes, causing membrane permeability changes that result in leakage of intracellular contents and cell death.
Uses of Liposomal Amphotericin B
It is used to treat fungal infections of one or more deep body organs. It is also used to treat suspected fungal infections in patients with a raised temperature and neutropenia (reduced number of white blood cells). It is also indicated to treat visceral leishmaniasis, a disease caused by a parasite in certain people.
Liposomal Amphotericin B Dosage available A doctor or nurse in a hospital or clinic setting will give it to you. It is given as an intravenous infusion drip (into your vein). Do not self-administer the injection. Your doctor will decide the dose and duration of the treatment based on your disease severity, body weight, and other factors.
Adalimumab
Description
This page contains brief details about the drug adalimumab, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Adalimumab is a monoclonal antibody (protein which attaches to a specific target) which was approved for its medical use on 31st December 2002.
Mechanism of Action of Adalimumab
Adalimumab Injection is a biological agent that acts as targeted drug therapy to treat various inflammatory conditions. Adalimumab specifically targets and binds to the tnf Alpha. tnf Alpha a protein that is present in high concentrations in inflammatory diseases. adalimumab blocks the interaction of this protein with its receptors and eventually lower the inflammation.
Uses of Adalimumab
Adalimumab Injection has been developed to treat various inflammatory conditions like rheumatoid arthritis, polyarticular juvenile idiopathic arthritis, enthesitis-related arthritis, ankylosing spondylitis, axial spondylarthritis without evidence of ankylosing spondylitis, psoriatic arthritis, plaque psoriasis, hidradenitis suppurativa, Crohn’s disease, ulcerative colitis and non-infective uveitis.
Adalimumab Dosage available
For adults with rheumatoid arthritis, psoriatic arthritis and ankylosing Spondylitis, the recommended dose is 40mg every other week. for children with Arthritis of unknown origin, the recommended dose is 10mg every other week for body weight less than 15 kg, 20mg every other week for body weight less than 30kg and 40mg every other week for body weight above 30kg.
For adults with inflammatory bowel disease like crohn’s disease and ulcerative colitis, the recommended dose is 160 MG on day 1, 80mg on 15th day and 40mg every other week starting on day 29. for children body weight less than 40 kg, the recommended dose is 80mg on first day, 40mg on day 15 and 20mg every other week starting on 29th day.
In case of plaque psoriasis and adult uveitis, initial dose is 80 mg followed by 40 mg every other week after initial dose. adalimumab is available as single dose prefilled pen (80mg/0.8ml, 40mg/0.8ml, 40mg/0.4ml) single dose prefilled glass syringe (80mg/0.8ml, 40mg/0.8ml, 40mg/0.4ml, 20mg/0.4ml, 20mg/0.2ml, 10mg/0.2ml, 10mg/0.1ml) and single dose glass vial (40mg/0.8ml).
Itolizumab
Description
This page contains brief details about the drug itolizumab, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Itolizumab is an immunomodulatory monoclonal antibody (protein which attaches to a specific target) which was approved for its medical use on January 2013.
Mechanism of Action of Itolizumab
Itolizumab Injection is a biological agent that belongs to the category of medications called monoclonal antibodies. Itolizumab specifically targets and binds to the domain 1 of the human CD6 cells, resulting in significant decrease in the inflammatory mediators. Itolizumab inhibits the availability of T cells without depleting them and eventually lowers the inflammation.
Uses of Itolizumab
Itolizumab Injection has been developed to treat moderate to severe plaque psoriasis, psoriatic arthritis and rheumatoid arthritis. It is also increasingly used to reduce inflammation and cytokine release in COVID-19 patients.
Itolizumab Dosage available
In case of plaque psoriasis and cytokine release syndrome, initial dose is 1.6mg/kg indicated as an intravenous infusion. For plaque psoriasis, a dose of 1.6mg/kg in administered every 2 weeks for 12 weeks, followed by 1.6mg/kg every 4 weeks up to 24 weeks. Approximately 50ml will be administered in the first hour, followed by the remaining dose within the next hour. For patients with cytokine release syndrome, the first infusion of 1.6mg/kg will be initiated at the rate of 25ml/hr in the first hour, followed by 50ml/hr for the next 5-6 hours if well tolerated. Itolizumab is available as single dose vial of injection, intended for IV infusion with each vial containing 100mg Itolizumab (rDNA origin).
Dasatinib
Description
This page contains brief details about the drug dasatinib, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Dasatinib is an anticancer agent which was approved for its medical use on 28th June 2006.
Mechanism of Action of Dasatinib
Dasatinib Tablet is a biological agent that acts as targeted drug therapy in cancer treatment. It is classified as a tyrosine kinase inhibitor. The BCR ABL tyrosine kinase enzymes are responsible for the uncontrolled generation of white blood cells in leukemia. Dasatinib binds to both active and inactive sites of BCR ABL tyrosine kinase enzyme to inhibit the uncontrolled growth of white blood cells.
Uses of Dasatinib
Dasatinib Tablet has been developed to treat Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia in adults, adolescents and children who have not benefitted from previous therapies. It is also approved for treating chronic myeloid leukemia.
Dasatinib Dosage available
The recommended starting dose for adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia is 140 mg per day. The ideal dose for children is calculated based on their body weight.
Dasatinib is available as a tablet in doses 20mg, 50mg, 70mg, and 100mg. It is advisable to take the tablets at the same time each day. Swallow them whole with some water and do not crush, cut or chew them.
Lopinavir+Ritonavir
Description
This page contains brief details about the drug lopinavir,ritonavir, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Lopinavir, Ritonavir is a combination of antiretroviral medicine developed by the U.S. Food And Drug Administration for treating HIV-1 infection.
Mechanism of Action of Lopinavir+Ritonavir
Lopinavir and Ritonavir work together to inhibit the protease enzyme, which is necessary for the replication of HIV. By blocking this enzyme, this drug prevents the virus from multiplying and spreading in the body. It mainly helps reduce the viral load and slow the progression of HIV infection.
Uses of Lopinavir+Ritonavir
Lopinavir, Ritonavir are used to treat Human Immunodeficiency Virus (HIV) in adults and adolescents over 12 who weigh at least 40 kg. HIV infection occurs when a person’s immune system is attacked and weakened by the human immunodeficiency virus (HIV). This infection progressively weakens the immune system, making individuals more susceptible to opportunistic infections.
Lopinavir+Ritonavir Dosage available
It is an orally available prescription drug. Your doctor will decide the dose and duration of the drug based on the disease condition and other factors. Always take Lopinavir and Ritonavir as prescribed by your doctor. Take the tablet with or without food. Do not break, chew, crush, or break the tablet. Swallow the whole tablet with water.
Melphalan
Description
This page contains brief details about the drug melphalan, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Melphalan is an anticancer drug that belongs to the class of medications called alkylating agents. FDA approved it initially in 1964 for treating multiple myeloma, advanced breast cancer, ovarian cancer, polycythemia vera, childhood neuroblastoma, malignant melanoma, and soft tissue sarcoma.
Mechanism of Action of Melphalan
Melphalan is an alkylating agent. It exerts its cytotoxic action primarily due to the cross-linking of strands of DNA and RNA, as well as the inhibition of protein synthesis. It works by stopping or slowing the growth of cancer cells in your body.
Uses of Melphalan
Melphalan is available as a tablet and injection. It is used to treat multiple myeloma (a type of cancer of the bone marrow). It is also used to treat advanced ovarian cancer. It is also indicated to treat childhood neuroblastoma (cancer of the nervous system), malignant melanoma (skin cancer), and soft tissue sarcoma (cancer of the muscle, fat, fibrous tissue, blood vessels, or other supporting tissues of the body). It is also indicated to treat polycythemia vera ( a disease that increases the number of red cells in your blood. This makes the blood thicken and causes blood clots). It works by reducing the number of abnormal cells your body makes.
Melphalan Dosage available
Melphalan is available as a tablet and injection. Melphalan injection will be administered to you by a doctor or other healthcare professional in a hospital setting trained in cancer chemotherapy. This injection can be given as an infusion into your vein, or it will be given as a perfusion to a particular part of your body through an artery. If you are prescribed the tablet. Take the tablet at the same time, with or without food. Do not break, chew, crush, or break the tablet. Swallow the whole tablet with water. Your doctor will decide the dose, route of administration, and duration of the therapy based on your disease status, severity, and other factors such as body weight, other disease conditions, and age.
Paclitaxel
Description
This page contains brief details about the drug paclitaxel, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Paclitaxel is a chemotherapeutic anticancer treatment drug which was approved for its medical use on December 1992.
Mechanism of Action of Paclitaxel
Paclitaxel is a chemotherapeutic agent that belongs to the category of medications called microtubule inhibitors. microtubules are structures that aid in the growth and development of cancer cells. Paclitaxel works by inhibiting these structures, ultimately stopping the multiplication of cancer cells. Paclitaxel is prescribed alone and also in combination with other anticancer medications.
Uses of Paclitaxel
Paclitaxel has been developed to treat certain forms of breast cancer, ovarian cancer, non-small cell lung cancer and AIDS-induced Kaposis sarcoma in patients who have not responded well to previous anticancer therapies.
Paclitaxel Dosage available
Paclitaxel is available in the form of injection in the doses 30mg, 100mg, 260mg and 300mg. Your healthcare provider will calculate the ideal dose according to your condition and administer it as an intravenous infusion after dilution.
Netupitant+Palonosetron
Description
This page contains brief details about the drug netupitant,palonosetron, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Netupitant, Palonosetron is an antiemetic drug that belongs to the category of medicines known as alkylating agents. It was approved by the FDA in July 2003 to treat Chemotherapy-induced nausea and vomiting.
Mechanism of Action of Netupitant+Palonosetron
It is a type of serotonin receptor antagonist, which works by blocking the action of serotonin in the body that induces nausea and vomiting. The chemotherapeutic trigger zone( CTZ) contains the receptor serotonin, when this CTZ is stimulated, vomiting occurs. Palonosetron prevents the signals from serotonin and helps to reduce the symptoms of nausea and vomiting.
Uses of Netupitant+Palonosetron
Netupitant, Palonosetron is an anti-emetic agent used to treat Postoperative nausea & vomiting. It is also used to treat Chemotherapy induced nausea & vomiting.
Netupitant+Palonosetron Dosage available
Netupitant,Palonosetron is a prescription drug available in tablet and injection form. The medicine will be administered to you by a healthcare professional in a hospital setting. This injection will be given intravenously into a vein in your arm or hand. Do not self-administer this medicine. The dose of the injection will be decided by your doctor based on your disease condition and other factors. Palonosetron Hydrochloride Injection is usually given about 30 minutes before you receive your anti-cancer medicine (chemotherapy) or right before anaesthesia for surgery. If you are taking palonosetron as an oral tablet, it should be swallowed whole with a glass of water, with or without food, as directed by your healthcare provider.