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Denosumab
Description
This page contains brief details about the drug denosumab, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
The U.S. FDA approved Denosumab for the first time on June 1, 2010, to treat postmenopausal women with osteoporosis at high risk for fracture.
Mechanism of Action of Denosumab
Osteoclast breaks the tissues in the bones and releases calcium into the blood. This process is called bone resorption. Denosumab acts by inhibiting osteoclast formation, thereby decreasing bone resorption and increasing bone mass and strength.
Uses of Denosumab
Osteoporosis in women postmenopause who are at high risk of fracture
Men with osteoporosis who are at increased risk of fracture
Bone loss in men due to reduced levels of testosterone caused as a result of prostate cancer surgery or treatment with medications
Osteoporosis in patients with a high risk of fracture due to long-term treatment with glucocorticoids.
And increase bone mass in women at high risk of fracture due to adjuvant aromatase inhibitor therapy for breast cancer.
Denosumab Dosage available
Denosumab is to be administered by a healthcare provider. It is injected subcutaneously under the skin of stomach, upper thigh or upper arm. Denosumab is to be given once every six months.
Degarelix
Description
This page contains brief details about the drug degarelix, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Degarelix is an anticancer medication that was approved for its medical use on 24th December 2008.
Mechanism of Action of Degarelix
Degarelix Injection is a biological agent that acts as hormonal drug therapy in cancer treatment. It is the only antagonist of Androgen Deprivation Therapy that works instantly to reduce testosterone levels. Degarelix is a gonadotropin-releasing hormone agonist that binds to the gonadotropin receptors of the pituitary gland. It lowers the release of gonadotrophin and testosterone, eventually inhibiting the development of cancer cells. Degarelix is prescribed alone and also with other anti-androgen medications to treat hormonal cancer.
Uses of Degarelix
Degarelix Injection has been developed to treat advanced prostate cancer in adult men.
Degarelix Dosage available Degarelix is available as a vial for injection in doses 80mg and 120mg. It is intended for administration through the subcutaneous route. The recommended initial dose is 240mg given as two 120 mg injections and 80mg is injected every 28 days as a maintenance dose.
Vinblastine
Description
This page contains brief details about the drug vinblastine, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Vinblastine is an anticancer drug that belongs to the category of medicines known as mitotic inhibitors. It was approved by the U.S. FDA in the year 1962 to treat Hodgkin’s and non-Hodgkin’s lymphoma.
Mechanism of Action of Vinblastine
It works by disrupting the formation of microtubules in cells. Microtubules are structures that help to support and shape cells, as well as transport molecules within cells. In cancer cells, microtubules play a key role in cell division and growth. By interfering with microtubule formation, this drug disrupts the ability of cancer cells to divide and grow, ultimately leading to their death.
Uses of Vinblastine
Vinblastine is used to treat Hodgkin’s and non-Hodgkin’s lymphoma, testicular cancer, breast cancer, and kaposi’s sarcoma.
Vinblastine Dosage available
The medicine will be administered to you by a healthcare professional in a hospital setting. Vinblastine is given as an injection into a vein (intravenous infusion) over a period of 30 minutes, once a day for up to 5 days. The dose, route of administration, and frequency will be decided by your doctor based on your disease condition and other factors.
Trientine Hydrochloride
Description
This page contains brief details about the drug trientine hydrochloride, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Trientine hydrochloride is a copper chelator used to treat Wilson disease in adult patients. FDA approved this medicine on May 02, 2022.
Mechanism of Action of Trientine Hydrochloride
Trientine hydrochloride is a copper chelating agent that binds excess copper in the body and assists in elimination from the body. It may also work by attaching to the copper in your stomach and stopping it from being absorbed.
Uses of Trientine Hydrochloride
Trientine hydrochloride is an orally available prescription drug. It is a copper chelator used to treat adult patients with stable Wilson’s disease who cannot tolerate any medicine used to treat the disease.
Trientine Hydrochloride Dosage available It is an orally available drug. The medicine is available in 250mg and 333mg capsules. Your doctor will decide the dose and duration of Trientine hydrochloride based on the disease condition and other factors. Always take this medicine as prescribed by your doctor. Swallow the capsules with water on an empty stomach (at least one hour before meals or two hours after meals, and at least one hour apart from any other medicines, food, or milk.) Do not break, chew, crush, or break the capsules.
Isavuconazole
Description
This page contains brief details about the drug isavuconazole, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Isavuconazole was first approved by the U.S. FDA on March 6, 2015.
Mechanism of Action of Isavuconazole
Isavuconazole produces fungicidal action by disrupting the biosynthesis of ergosterol. Ergosterol is an essential component of the fungal cell membrane. Disruption of ergosterol leads to reduced structural integrity, cell membrane function and causes inhibition of fugal growth and replication, thereby causing cell death.
Uses of Isavuconazole
Isavuconazole is an azole antifungal medication used to treat Invasive Aspergillosis and Invasive Mucormycosis.
Isavuconazole Dosage available
Isavuconazole is to be administered as prescribed by your healthcare provider. It is administered by two ways.
Isavuconazole capsule is administered either orally with or without food. Isavuconazole injection is administered as an infusion into the vein.
Irinotecan
Description
This page contains brief details about the drug irinotecan, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Irinotecan is an anti-cancer drug that belongs to the camptothecin analogs. The FDA approved it on August 24, 2004, to treat colon and rectum metastatic carcinoma.
Mechanism of Action of Irinotecan
Irinotecan works by converting its active metabolite with the help of liver enzymes and inhibits the Topoisomerase I enzyme. This causes damage to the DNA synthesis and its replication, thus preventing the cancer cells from growing and spreading.
Uses of Irinotecan
Irinotecan is a topoisomerase enzyme inhibitor used as a first-line therapy in combination with other anti-cancer medications to treat colon and rectum cancers and extensive-stage non-small cell lung cancer. It is also indicated to treat gastric cancers. Irinotecan is currently under investigation to treat ovarian and cervical cancer.
Irinotecan Dosage available
Irinotecan is a prescription drug available as an injection to be administered for over 90 minutes intravenously (into the vein), followed by other chemotherapeutic drugs. The drug will be prescribed and administered by the healthcare professional. It is normally administered no more than once a week, according to the schedule, on which days you receive irinotecan and on which days you dont receive the medication. Your doctor will determine the optimum schedule for you. Antiemetic medications may be given priorly to prevent nausea and vomiting associated with the treatment.
Ifosfamide With Mesna
Description
This page contains brief details about the drug ifosfamide,mesna, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Ifosfamide, Mesna are alkylating agents and hemorrhagic cystitis inhibitors which was approved for its medical use in the year 1998.
Mechanism of Action of Ifosfamide With Mesna
These two combinations together work by damaging the DNA in cancer cells, which leads to cell death and slows the growth and spread of cancer. Mostly, this involves the formation of reactive metabolites in the liver, which are then transported to cancer cells in the body. These metabolites react with the DNA in the cancer cells, causing cross-links and breaks in the DNA strands. This interferes with the replication and transcription of DNA, leading to cell death.
Uses of Ifosfamide With Mesna
Ifosfamide, Mesna are indicated for the treatment of bladder inflammation, hemorrhagic cystitis and cancers in the soft tissues, germ cell, pancreas and cervix.
Ifosfamide With Mesna Dosage available
It will be given to you by a doctor or nurse in a hospital or clinic setting trained in cancer chemotherapy. Ifosfamide, Mesna is given as an intravenous infusion drip (into your vein). Do not self-administer the injection. Your doctor will decide the dose and duration of the treatment based on your disease severity, body weight, and other factors. Your doctor will give you certain medications to lessen the chance of getting side effects from the Ifosfamide, Mesna treatment.
Gemcitabine
Description
This page contains brief details about the drug gemcitabine, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
The U.S. FDA approved Gemcitabine as a chemotherapeutic anticancer medication to treat bladder, breast, ovarian, pancreatic, and non-small cell lung cancers on 10th January 1995.
Mechanism of Action of Gemcitabine
Gemcitabine is a cytotoxic agent belonging to the category of medications called antimetabolites. It inhibits DNA polymerase enzyme, breaks the DNA strands, interferes with cell signalling and eventually prevents the multiplication of cancer cells. Gemcitabine is prescribed alone and also in combination with other anticancer medications like Cisplatin and Carboplatin.
Uses of Gemcitabine
Gemcitabine has been developed to treat ovarian cancer, breast cancer, non-small cell lung cancer, and pancreatic cancer in patients who have failed to respond to previous therapies.
Gemcitabine Dosage available
Gemcitabine is available for administration as an intravenous infusion that is injected through the veins of patients with ovarian, breast, and non-small cell lung cancer. Your physician will choose the dosage and administration frequency based on your medical condition and type of cancer because it differs for each person.
Methylprednisolone
Description
This page contains brief details about the drug methylprednisolone, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Methylprednisolone is an anti-inflammatory drug that belongs to the category of medicines known as glucocorticoids. It was approved by the FDA in 1957.
Mechanism of Action of Methylprednisolone
It works by binding to glucocorticoid receptors and inhibits the production of substances (such as prostaglandins) that lead to inflammation and allergies.
Uses of Methylprednisolone
Methylprednisolone is used to treat inflammatory and allergic conditions in the body. It is also used for the treatment of endocrine disorders.
Methylprednisolone Dosage available
The medicine will be administered to you by a healthcare professional in a hospital setting. This injection will be given intramuscularly or intravenously into a vein in your arm. Do not self-administer this medicine. 40 mg/mL and 80 mg/mL. The dose of the injection will be decided by your doctor based on your disease condition and other factors.
Plerixafor
Description
This page contains brief details about the drug plerixafor, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
The U.S. FDA-approved Plerixafor is used to collect blood stem cells. Additionally, it is also used in lymphoma (WBC cancer), multiple myeloma (plasma cell cancer in bone marrow), or solid tumor On 15th December 2008.
Mechanism of Action of Plerixafor
Plerixafor injection works by blocking a protein called CXCR4 (chemokine receptor) on stem cells, which helps them move from the bone marrow into the bloodstream. By blocking CXCR4, Plerixafor causes the stem cells to be released into the bloodstream where the stem cells can be collected and isolated using a machine and stored for transplantation.
Uses of Plerixafor
Plerixafor is used to collect blood stem cells for collection, storage, and transplantation., lymphoma and multiple myeloma in adults, lymphoma or solid tumors in children (aged between 1 to 18).
Plerixafor Dosage available
Plerixafor injection is administered as a subcutaneous injection (under your skin). If this injection is recommended for you, it will be given by a healthcare professional. Do not self-administer. Your physician will choose the dosage and administration frequency based on the medical condition because it differs for each person.