Advagraf (Tacrolimus) Capsule

Description

Description

This page contains brief details about the drug tacrolimus, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Date of Approval

Tacrolimus is an immunosuppressant that was approved for its medical use on 8th April 1994.

Mechanism of Action of Tacrolimus

Tacrolimus is an immunosuppressant that prevents organ rejection in organ transplantation. It is classified as an immunosuppressant belonging to the category of Calcineurin inhibitors. Tacrolimus works by binding to a protein called FKBP-12 and forms a complex called tacrolimus-FKBP, which inhibits the action of calcineurin phosphatase. This, in turn, inhibits the formation of T cells and suppresses the immune response. Tacrolimus is often prescribed along with other immunosuppressants like azathioprine and mycophenolate mofetil.

Uses of Tacrolimus

Tacrolimus has been developed to prevent organ rejection in adult and pediatric patients receiving an allogeneic transplant of the liver, kidney, heart, or lung.

Tacrolimus Dosage available

Tacrolimus is available in the form of capsules, injections, oral suspensions, and ointments. Tacrolimus Capsule is available in doses 0.5mg, 1mg, and 5mg. your healthcare provider will administer Tacrolimus Injection (5mg/ml) if you are unable to tolerate an oral capsule or suspension. Your healthcare provider will prescribe the accurate dose based on the organ transplanted, body weight, and health condition. Patients diagnosed with cystic fibrosis might require higher doses.