Atgam (Antithymocyte Immunoglobulins) Tablet

Description

Description

This page contains brief details about the drug antithymocyte immunoglobulins, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Date of Approval

Antithymocyte Immunoglobulins contain the active ingredient Antithymocyte immunoglobulins. It is a purified and sterile form of gamma globulin. It is isolated from the hyperimmune plasma of horses immunized with human white blood cell components. It is used after kidney transplantation and other therapies to treat and delay organ rejection. After solid organ transplantation, the body generates an aggressive immune response because it recognizes the transplanted organ’s antigens as a foreign antigens. Thus, treatment with immunosuppressive agents is necessary after an organ transplant to prevent organ rejection. Antithymocyte immunoglobulin received initial FDA approval on November 16, 1998.

Mechanism of Action of Antithymocyte Immunoglobulins

The therapeutic effect of antithymocyte immunoglobulins is the suppression of the immune response by targeting and depleting T lymphocytes. This effect is beneficial in preventing organ rejection in solid organ transplantation, where this medication helps increase the success of transplantation and improve graft survival rates.

Additionally, these are used to treat conditions such as aplastic anemia and graft-versus-host disease (GVHD), where the immune system attacks the body’s cells or tissues. Modulating the immune response reduces immune-mediated damage, alleviates symptoms, and promotes restoring normal cell production.

Uses of Antithymocyte Immunoglobulins

Antithymocyte immunoglobulins tablets are used for multiple purposes, including preventing organ rejection in organ transplantation, treating aplastic anemia, managing kidney rejection in renal allograft recipients, addressing autoimmune hemolytic anemia, and managing myasthenia gravis, a bone disorder.

Antithymocyte Immunoglobulins Dosage available

Antithymocyte immunoglobulins are typically administered intravenously injection in a hospital or clinical setting. Your healthcare provider will determine the specific dosage and infusion rate based on factors such as the condition being treated, your body weight, and your response to the medication.