Azalive (Azacitidine) Injection

Generic brands for Azacitidine Injection  Available in India Brand Name Azalive Generic Name Azacitidine Strength 100mg, 200mg Manufacturer Abbott

Description

Description

This page contains brief details about the drug azacitidine, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Date of Approval

Azacitidine is an anticancer medication which was approved for its medical use on 19th May 2004.

Mechanism of Action of Azacitidine

Azacitidine is a cytotoxic anticancer medication belonging to the category of medications called antimetabolites. It is also called as the demethylating or hypomethylating agent. It enters the DNA and forms a covalent bond with the DNA methyltransferase and induces programmed cell death of tumour cells.

Uses of Azacitidine

Azacitidine is a prescription medicine indicated to treat adults with acute myeloid leukemia and myelodysplastic syndrome and peadiatric patients older than one month newly diagnosed with Juvenile Myelomonocytic Leukemia (JMML).

Azacitidine Dosage available

Azacitidine is available in form of tablets in the doses 200mg and 300mg and as lyophilized powder for injection in the doses 100mg and 150mg. the injection is intended for administration through subcutaneous and intravenous route only.

Take 1 Azacitidine Tablet with or without food everyday from day 1 to day 14 of each 28-day cycle. Azacitidine Injection will be administered by your oncologist through subcutaneous or intravenous route and the number of cycles and duration of treatment depends on the type of cancer.

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News/Updates

References

  1. Bristol Myers Squibb, [Revised on May 2021] [Accessed on 12th Oct 2022], https://packageinserts.bms.com/pi/pi_onureg.pdf
  2. Bristol Myers Squibb, [Revised on Sep 2022] [Accessed on 12th Oct 2022], https://packageinserts.bms.com/pi/pi_vidaza.pdf
  3. Anton Wellstein, Giuseppe Giaccone, Michael B. Atkins, and Edward A. Sausville, Goodman & Gilman’s Pharmacological Basis of Therapeutics, Cytotoxic Drugs, 13th Edition, 2018, 1167-1201.
  4. Čemažar L, Podgornik H, Šimec NG, Zver S. Successful long-term treatment with azacitidine in patient with chronic myelomonocytic leukemia. Hematol Rep. 2020 Dec 2;12(3):8537, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731662/pdf/hr-12-3-8537.pdf