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Bufatas IV (Busulfan) Injection
Generic brands for Busulfan Injection Available in India Brand Name Bufatas IV Generic Name Busulfan Strength 60mg Manufacturer Intas Pharmaceuticals Ltd
Description
Description
This page contains brief details about the drug busulfan, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Busulfan is an anti-cancer medication that was approved to be used on 2 April 1999.
Mechanism of Action of Busulfan
Busulfan is an alkylating chemotherapeutic agent that works by interfering with the DNA replication process, which is necessary for the cells to divide. It stops tumor growth by inhibiting cell division.
Uses of Busulfan
Busulfan is used to treat
Hematopoietic progenitor cell transplantation
Chronic myelogenous leukemia
Polycythaemia vera (a type of cancer that causes an increase in red blood cells)
Thrombocythemia (increased number of platelets in the blood)
Myelofibrosis (type of blood cancer where scar tissues are formed in bone marrow)
Hemoglobinopathies (a genetic disorder that produces abnormal hemoglobin)
Brain Malignancies
Busulfan Dosage available
Busulfan is available as a tablet that is to be swallowed whole with water. The available dose is 2mg.
Busulfan is an injection that is to be given only under the supervision of a qualified healthcare professional. The available dose is 6omg.
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News/Updates
References
- Aspen, Electronic Medicines Compendium (EMC) (Revised on July 2020), (Accessed on 11th January 2023), https://www.medicines.org.uk/emc/product/4653/pil#gref
- Anton Wellstein, Giuseppe Giaccone, Michael B. Atkins, and Edward A. Sausville, Pharmacotherapy of Neoplastic disease: cytotoxic drugs, Goodman & Gilman’s Pharmacological Basis of Therapeutics, 13th Edition, 2018, 1167-1174.
- Buggia I, Locatelli F, Regazzi MB, Zecca M. Busulfan. Ann Pharmacother. 1994 Sep;28(9):1055-62. doi: 10.1177/106002809402800911. PMID: 7803883.
- Drug Approval Package, U.S. FDA, https://www.accessdata.fda.gov/drugsatfda_docs/nda/99/20954.cfm