Cabaxan (Cabazitaxel) Injection

Generic brands for Cabazitaxel Injection Available in India Brand Name Cabaxan Generic Name Cabazitaxel Strength 60mg Manufacturer Intas Pharmaceuticals Ltd

Description

Description

This page contains brief details about the drug cabazitaxel, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Date of Approval

Cabazitaxel is an anti-cancer drug that belongs to the category of medicines known as alkylating agents. It was approved by the U.S.U.S. FDAFDA in June 2010 to treat metastatic castration-resistant prostate cancer (mCRPC).

Mechanism of Action of Cabazitaxel

It is a mitotic inhibitor that works by disrupting the normal process of cell division. This interferes with the microtubules that help to form the cell’s cytoskeleton. Microtubules are essential for the normal process of cell division, as they help to pull apart the chromosomes during mitosis. By inhibiting microtubules, cabazitaxel prevents the cancer cells from dividing properly and ultimately leads to their death.

Uses of Cabazitaxel

Cabazitaxel is a cytotoxic agent used with steroid medicine prednisone or prednisolone to treat people with hormone-refractory metastatic prostate cancer that has progressed after treatment with other anticancer medications, including docetaxel.

Cabazitaxel Dosage available

The medicine will be administered to you by a healthcare professional in a hospital setting. The recommended dose for cabazitaxel is 25mg, administered as an intravenous infusion over one hour every three weeks, in combination with oral prednisone (10 mg daily). The dose can be adjusted based on individual patient factors, such as age, body weight, and other medical conditions.

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News/Updates

References

  1. Annex I summary of Product Characteristics – European Medicines Agency. Available at:https://www.ema.europa.eu/en/documents/product-information/jevtana-epar-product-information_en.pdf [ Accessed on 29th March 2023]
  2. Package leaflet: Information for the user. www.hpra.ie.http://www.hpra.ie/img/uploaded/swedocuments/5a5602f0-c957-440b-b07b-fc5ca51d21ca.pdf [ Accessed on 29th March 2023]
  3. Bertram.G.Katzung, Basic and Clinical Pharmacology, Cancer Chemotherapy, 14th edition, 2017, 963.