Letronat (Letrozole) Tablet

Generic brands for Letrozole Tablet Available in India Brand Name Letronat Generic Name Letrozole Strength 2.5mg Manufacturer Natco Pharma Ltd  

Description

Description

This page contains brief details about the drug letrozole, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Date of Approval

The U.S. FDA approved Letrozole as an anticancer medication to treat t early and advanced hormone receptor-positive breast cancer in postmenopausal women on  25th July 1997.

Mechanism of Action of Letrozole

Letrozole is a nonsteroidal compound that inhibits estrogen production by blocking the enzyme aromatase. This medicine reduces the tumor size and stops or slows the progression of the disease, avoiding the reoccurring of early-stage breast cancer and improving the survival rate.

Uses of Letrozole

Letrozole tablet has been developed to treat early and advanced hormone receptor-positive breast cancer in postmenopausal women who have not responded to Tamoxifen therapy. It is also used to support standard treatment for postmenopausal women with early breast cancer.

Letrozole Dosage available

Letrozole is available as a film-coated tablet indicated for oral intake with or without meals. The usual recommended dose is 2.5mg daily, but your physician will choose the dosage and administration frequency incase if you have a liver impairment or any other medical condition.

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News/Updates

References

  1. Cipla (EU) Limited, Electronic Medicines Compendium (EMC), [Revised on Oct 2021], [Accessed on 22th Mar 2023], https://www.medicines.org.uk/emc/files/pil.9957.pdf
  2. Novartis Pharmaceuticals Corporation, [Revised on May 2020], [Accessed on 22th Mar 2023], https://www.novartis.us/sites/www.novartis.us/files/Femara.pdf?TB_iframe=true
  3. HIGHLIGHTS OF PRESCRIBING INFORMATION. (n.d.). [online] www.accessdata.fda.gov. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/020726s027lbl.pdf [Accessed on 22th Mar 2023].
  4. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.
  5. KD Tripathi, Estrogens, Progestins and Contraceptives, Essentials of Medical Pharmacology, 8th Edition, 2019, 330-353.