Merinethol 50mg (Mercaptopurine) Tablet

Description This page contains brief details about the drug mercaptopurine, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects. Date of Approval Mercaptopurine is an anticancer drug that belongs to the class of medicines known as purine antagonists. It was approved by the U.S. FDA on 28th […]

Description

Description

This page contains brief details about the drug mercaptopurine, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Date of Approval

Mercaptopurine is an anticancer drug that belongs to the class of medicines known as purine antagonists. It was approved by the U.S. FDA on 28th of April 2014 to treat acute lymphoblastic leukaemia.

Mechanism of Action of Mercaptopurine

It works by interfering with the DNA and RNA function in cancer cells, inhibiting nucleotide synthesis, suppressing the immune system, and activating enzymes that can kill cancer cells. It is usually used in combination with other chemotherapy drugs to increase its effectiveness.

Uses of Mercaptopurine

Mercaptopurine is used in the treatment of acute lymphoblastic leukaemia.

Mercaptopurine Dosage available

Mercaptopurine is to be administered orally. Swallow the whole tablet with water. If you forgot to take the tablet, simply take your next dose at the scheduled time. Do not take a double dose to make up for a forgotten dose. You must take these tablets at least 1 hour before or 2 hours after having milk or dairy products.

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References

Aspen Pharma Trading Limited, Electronic medicines compendium (EMC), [ Revised on August 2019] (Accessed: April 6, 2023), https://www.medicines.org.uk/emc/files/pil.4655.pdf

Purinethol® (mercaptopurine) 50-mg scored tablets caution. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/009053s032lbl.pdf (Accessed: April 6, 2023).

Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Cytotoxic agents, 12th edition, 2011, 1701 – 1702.

KD Tripathi, Essentials of Medical Pharmacology, Anticancer drugs, 7th edition, 2013, 863.