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Sandimmun Neoral (Cyclosporine) Capsule
Generic brands for Cyclosporine Injection Available in India Brand Name Sandimmun Neoral Generic Name Cyclosporine Strength 25mg, 50mg, 100mg Manufacturer Novartis India Ltd
Description
Description
This page contains brief details about the drug cyclosporine, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.
Date of Approval
Cyclosporine is an immunosuppressant which was approved for its medical use on 1983.
Mechanism of Action of Cyclosporine
Cyclosporine is an immunosuppressant which prevents organ rejection in organ transplantation. It is classified as an immunosuppressant belonging to the category of Calcineurin inhibitors. Cyclosporine works inhibiting cytochrome P450 3A4, P-glycoprotein and interleukins to suppress the cell mediated immune response. Cyclosporine is often prescribed along with other immunosuppressants like azathioprine and mycophenolate mofetil.
Uses of Cyclosporine
Cyclosporine has been developed to prevent organ rejection in adult and pediatric patients receiving an allogeneic transplant of the liver, kidney, heart, or lung. it is indicated for It is also prescribed to treat rheumatoid arthritis for patients who have not responded adequately to methotrexate.
Cyclosporine Dosage available
Cyclosporine is available in the form of capsule, injection and oral solution. Cyclosporine Capsule is available in the doses 25mg, 50mg and 100mg. Your healthcare provider will administer Cyclosporine 50mg Injection if you are unable to tolerate oral capsule or suspension. Your healthcare provider will prescribe the accurate dose based on the organ transplanted, body weight and health condition.
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References
1. Novartis Pharmaceuticals UK Limited, Electronic Medicines Compendium (EMC), [Revised on May 2022] [Accessed on 15th Sep 2022], https://www.medicines.org.uk/emc/files/pil.1036.pdf
2. AbbVie Inc., [Revised on Feb 2021] [Accessed on 15th Sep 2022], https://www.rxabbvie.com/pdf/gengraf-oral.pdf
3. AbbVie Inc., [Revised on Feb 2021] [Accessed on 15th Sep 2022], https://www.rxabbvie.com/pdf/gengraf-cap.pdf
4. Alan M. Krensky, Jamil R. Azzi, and David A. Hafler, Goodman & Gilman’s Pharmacological Basis of Therapeutics, Immunosuppressants and Tolerogens, 13th Edition, 2018, 637-653.
5. Carolina Tapia; Trevor A. Nessel; Patrick M. Zito, Cyclosporine, StatPearls [Internet], [Revised on 15th Nov 2021] [Accessed on 15th Sep 2022], https://www.ncbi.nlm.nih.gov/books/NBK482450/