Tagrisso (Osimertinib) Tablet

Generic brands for Osimertinib Tablet Available in India Brand Name Tagrisso Generic Name Osimertinib Strength 40mg, 80mg Manufacturer Astrazeneca Pharma India

Description

Description

This page contains brief details about the drug osimertinib, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Date of Approval

Osimertinib is an anticancer medication that the Food and Drug Administration approved on the 18th of April 2018 as a first-line treatment for patients having non-small cell lung cancer (NSLC), that has spread to other parts and whose tumors have epidermal growth factor receptor (EGFR) mutations.

Later on the 18th of December 2020, Osimertinib got approval for being used as an additional therapy after tumor removed by surgery in patients having metastatic non-small cell lung cancer (NSLC) whose tumors have epidermal growth factor receptor (EGFR) mutations.

Mechanism of Action of Osimertinib

Osimertinib is a targeted therapy medication and belongs to the category of oral EGFR kinase inhibitor. It works by producing inhibitory action on the Epidermal growth factor receptor (EGFR) and retards the growing cancer cells. Osimertinib also works by slowing down or stopping lung cancer from growing and reducing the tumor size. In addition, it also works by preventing the recurrence of the tumor after its removal through surgery.

Uses of Osimertinib

Osimertinib is indicated to treat non-small cell lung cancer (NSCLS) in adults. It is also used as a first-line treatment for patients having metastatic non-small cell lung cancer (NSLC) whose tumors have epidermal growth factor receptor (EGFR) mutations. In addition, it is also used after the removal of tumors by surgery.

Osimertinib Dosage available

Osimertinib is an prescription medicine available as a tablet in two doses Osimertinib 40mg and Osimertinib 80mg. This medication is to be taken by mouth and swallowed as a whole with or without food at the same time every day as prescribed by your doctor. It should not be crushed, split, or chewed.  If you cannot swallow the tablets, you can dissolve them as per your doctor’s advice.

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References

  1. TAGRISSO 80 mg film-coated tablets – Patient Information Leaflet (PIL) – (emc) [Internet]. www.medicines.org.uk. [Revised on July 2022] [cited 2023 Mar 28]. Available from: https://www.medicines.org.uk/emc/product/7615/pil
  2. Highlights Of Prescribing Information – Osimertinib. [revised on 2020] [cited 2023 Mar 28]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/208065s021lbl.pdf
  3. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.

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