Zoledac (Zoledronic Acid) Injection

Generic brands for Zoledronic Acid Injection  Available in India Brand Name Zoledac  Generic Name Zoledronic Acid Strength 4mg Manufacturer Aureate Healthcare Pvt Ltd

Description

Description

This page contains brief details about the drug zoledronic acid, it’s indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Date of Approval

Zoledronic Acid is an anti-resorptive medication which was approved for its medical use on 22nd February 2002.

Mechanism of Action of Zoledronic Acid

Zoledronic Acid Injection is an anti-resorptive medication that belongs to the class of bisphosphonates. Zoledronic acid works by inhibiting the cell signaling pathways that produce osteoclasts. This process further inhibits bone resorption and also induces programmed cell death of cancer cells.

Uses of Zoledronic Acid

Zoledronic Acid Injection has been developed to treat osteoporosis and prevent bone complications in patients diagnosed with bone cancer. A condition called tumor-induced hypercalcemia is common among people diagnosed with cancer. Zoledronic acid Injection is indicated to reduce blood calcium levels in such conditions.

Zoledronic Acid Dosage available

Zoledronic Acid Injection is available as a single-dose vial for injection in doses 4mg and 5mg. It is intended for administration as an intravenous infusion after reconstitution. Your healthcare provider will prescribe an accurate dose depending on your health condition. If you have been diagnosed with a kidney problem, your doctor will administer a lower dose.

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References

1. KD Tripathi, Hormones and Drugs Affecting Calcium Balance, Essentials of Medical Pharmacology, 8th Edition, 2019, 360-372.

2. Seacross Pharmaceuticals Ltd, Electronic Medicines Compendium (EMC), [Revised on Nov 2021] [Accessed on 14th Sep 2022], https://www.medicines.org.uk/emc/files/pil.7205.pdf

3. Wang, L., Fang, D., Xu, J. et al. Various pathways of zoledronic acid against osteoclasts and bone cancer metastasis: a brief review. BMC Cancer 20, 1059, Published on 2020, [Accessed on 14th Sep 2022], https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-020-07568-9.pdf